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PIEZO2 Antibody SKU: NBP1-89892
Host
Rabbit
Rabbit
Reactivity
Human
Human
Applicable Processes
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Scientific Score
6.88
Brand
Novus Biologicals
Sizes
1 (0.1 ml)
Available From
1 Vendor
Price
$ 441.87
Catalog IDs
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PIF1 Antibody [Alexa Fluor 405] SKU: NBP1-97931AF405
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.19
Brand
Novus Biologicals
Sizes
1 (100 Tests)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIF1 Antibody [Alexa Fluor 488] SKU: NBP1-97931AF488
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.19
Brand
Novus Biologicals
Sizes
1 (100 Tests)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIF1 Antibody [Alexa Fluor 647] SKU: NBP1-97931AF647
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.19
Brand
Novus Biologicals
Sizes
1 (100 Tests)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIF1 Antibody [Alexa Fluor 700] SKU: NBP1-97931AF700
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.19
Brand
Novus Biologicals
Sizes
1 (100 Tests)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIF1 Antibody [DyLight 405] SKU: NBP1-97931V
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.78
Brand
Novus Biologicals
Sizes
1 (0.1 ml)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIF1 Antibody [FITC] SKU: NBP1-97931F
Host
Rabbit
Rabbit
Reactivity
Murine
Murine
Applicable Processes
Immunohistochemistry
Immunohistochemistry
Scientific Score
6.78
Brand
Novus Biologicals
Sizes
1 (0.1 ml)
Available From
1 Vendor
Price
$ 358.28
Catalog IDs
Added to comparison remove item
PIST Antibody SKU: NBP1-88222
Host
/
Reactivity
/
Applicable Processes
/
Scientific Score
2.95
Brand
Novus Biologicals
Sizes
1 (1 Pack)
Available From
1 Vendor
Price
$ 441.87
Catalog IDs
Added to comparison remove item
PITX1 Antibody SKU: NBP1-88644
Host
Rabbit
Rabbit
Reactivity
Human
Human
Applicable Processes
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Scientific Score
6.88
Brand
Novus Biologicals
Sizes
1 (0.1 ml)
Available From
1 Vendor
Price
$ 441.87
Catalog IDs
Added to comparison remove item
PKHD1 Antibody SKU: NBP1-89003
Host
/
Reactivity
/
Applicable Processes
/
Scientific Score
2.95
Brand
Novus Biologicals
Sizes
1 (1 Pack)
Available From
1 Vendor
Price
$ 441.87
Catalog IDs
Added to comparison remove item
PKLR Antibody (1E3) SKU: NBP1-97937
Host
Murine
Murine
Reactivity
Human
Human
Applicable Processes
ELISA, Western blot
ELISA, Western blot
Scientific Score
7.53
Brand
Novus Biologicals
Sizes
1 (100 µl)
Available From
1 Vendor
Price
$ 286.42
Catalog IDs
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Plakophilin-3 Antibody (23E3/4) [DyLight 350] SKU: NBP1-97674UV
Host
Murine
Murine
Reactivity
Canine, Human, Murine
Canine, Human, Murine
Applicable Processes
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western blot
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western blot
Scientific Score
6.88
Brand
Novus Biologicals
Sizes
1 (100 Tests)
Available From
1 Vendor
Price
$ 512.27
Catalog IDs
Added to comparison remove item

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Primary Antibody Structure & Function

Primary antibodies, a subgroup of immunoglobulins known as glycoproteins, specifically bind to one antigen or protein with high affinity. This is not to be confused with a secondary antibody, which binds to another (primary) antibody that is linked to another molecule.

Primary antibodies are extremely useful for detecting disease biomarkers in cancer, diabetes, Parkinson′s and Alzheimer′s disease. One example of such uses is with Pharmacokinetics, the study of how an organism affects a drug (e.g. digestion and metabolization). Here, antibodies are used for ADME (absorption, distribution, metabolism, and excretion) and testing multi-drug resistance (MDR).

Monoclonal and Polyclonal Antibodies

Mice, rats, and goats are used to produce primary antibodies, which are either polyclonal (pAb) or monoclonal (mAb). Polyclonal antibodies are derived from different B-cell lineages, thus producing a mixture of antibodies with varying levels of affinity which target multiple epitopes. Monoclonal antibodies are sourced from one B-cell lineage, thus producing highly specific antibodies with only one antibody subtype.

Use in Cell Biology

Primary antibodies are key components in cell biology for processes such as:

  • apoptosis

  • cell stress

  • cell cycle progression

  • cell signaling

  • cytoskeleton and extracellular matrix (ECM) organization

  • gene expression

  • metabolism

  • protein synthesis and degradation

  • enzyme phenotype profiling

  • ion channel transport

Use in Gene Expression

Primary antibodies are useful in monitoring gene expression as part of detection systems which use a broad range of markers including b-galactosidase, biotin, digoxin, and DNP.

Other systems make use of protein fusion tags. These can consist of: alkaline phosphatase, FLAG, glutathione-S-transferase (GST), hemagglutinin (HA), maltose binding protein (MBP), c-myc, polyhistidine, thioredoxin, and peroxidase.

Primary antibodies can also monitor changes in phenotypes and status of the proteasome under normal and diseased conditions.

Leukocyte antigen and cytokine expression can also be measured; CD antigens (a type of leukocyte antigen) can help distinguish cell lineage, and functional subsets including:

  • integrins

  • selectins

  • human leukocyte (HLA) antigens (histocompatibility antigens (glycoproteins)

  • interferons

  • interleukins

  • tumor necrosis factor (TNF)

Concentration and Modification Measurement

Aside from detection, primary antibodies can also be used to measure concentration changes as well as specific modifications such as phosphorylation, methylation, or glycosylation. This allows for the study of proteins which are activated, silenced, processed or causing disease.