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Primary Antibodies on ZAGENO

MITF Antibody (3F276) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Kit)
Sizes 1 (1 Kit)
Catalog IDs sc-71588
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NF2 Antibody (B-12) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Kit)
Sizes 1 (1 Kit)
Catalog IDs sc-55575
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Nkx-2.5 Antibody (A-3) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Kit)
Sizes 1 (1 Kit)
Catalog IDs sc-376565
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IRF3 (phospho Ser396) antibody GeneTex
Reagent Type Antibodies Applicable Processes Blotting, ELISA Quantity 100 μl
From $ 299.00 (100 μl)
Sizes 1 (100 μl)
Catalog IDs GTX86691
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Mouse Anti-HA IgG:SureLight® R-PE Cayman Chemical
Reagent Type / Applicable Processes / Quantity /
From $ 323.00 (100 μg)
Sizes 1 (100 μg)
Catalog IDs 13429
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Anti-fibrillarin: mouse Mab Cytoskeleton
Reagent Type Antibodies Applicable Processes / Quantity 100 µg
From $ 285.00 (100 µg)
Sizes 1 (100 µg)
Catalog IDs AFB01
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Anti-HES1 (Hairy Family Helix-loop-helix Transcription Factor) United States Biological
Reagent Type Antibodies Applicable Processes Immunofluorescence, Immunohistochemistry, Western blot Quantity 100 µg
From $ 596.00 (100 µg)
Sizes 1 (100 µg)
Catalog IDs H2034-35
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Jackson Immuno Research LabsSupplier Diversity Partner GOAT ANTI MOUSE IGG HRP Jackson ImmunoResearch Laboratories
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 131.44 (1 Vials)
Sizes 1 (1 Vials)
Catalog IDs NC9491974
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cyclin G1 (F-5) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes Western blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry, ELISA Quantity /
From $ 279.00 (1 Packs)
Sizes 1 (1 Packs)
Catalog IDs sc-8016
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p21 (F-5) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Packs)
Sizes 1 (1 Packs)
Catalog IDs sc-6246
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p-Tyr (PY20) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Packs)
Sizes 1 (1 Packs)
Catalog IDs sc-508
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PARP-1 (F-2) Santa Cruz Biotechnology
Reagent Type Antibodies Applicable Processes / Quantity /
From $ 279.00 (1 Packs)
Sizes 1 (1 Packs)
Catalog IDs sc-8007
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Primary Antibody Structure & Function

Primary antibodies, a subgroup of immunoglobulins known as glycoproteins, specifically bind to one antigen or protein with high affinity. This is not to be confused with a secondary antibody, which binds to another (primary) antibody that is linked to another molecule.

Primary antibodies are extremely useful for detecting disease biomarkers in cancer, diabetes, Parkinson′s and Alzheimer′s disease. One example of such uses is with Pharmacokinetics, the study of how an organism affects a drug (e.g. digestion and metabolization). Here, antibodies are used for ADME (absorption, distribution, metabolism, and excretion) and testing multi-drug resistance (MDR).

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Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Monoclonal and Polyclonal Antibodies

Mice, rats, and goats are used to produce primary antibodies, which are either polyclonal (pAb) or monoclonal (mAb). Polyclonal antibodies are derived from different B-cell lineages, thus producing a mixture of antibodies with varying levels of affinity which target multiple epitopes. Monoclonal antibodies are sourced from one B-cell lineage, thus producing highly specific antibodies with only one antibody subtype.

Use in Cell Biology

Primary antibodies are key components in cell biology for processes such as:

  • apoptosis

  • cell stress

  • cell cycle progression

  • cell signaling

  • cytoskeleton and extracellular matrix (ECM) organization

  • gene expression

  • metabolism

  • protein synthesis and degradation

  • enzyme phenotype profiling

  • ion channel transport

Use in Gene Expression

Primary antibodies are useful in monitoring gene expression as part of detection systems which use a broad range of markers including b-galactosidase, biotin, digoxin, and DNP.

Other systems make use of protein fusion tags. These can consist of: alkaline phosphatase, FLAG, glutathione-S-transferase (GST), hemagglutinin (HA), maltose binding protein (MBP), c-myc, polyhistidine, thioredoxin, and peroxidase.

Primary antibodies can also monitor changes in phenotypes and status of the proteasome under normal and diseased conditions.

Leukocyte antigen and cytokine expression can also be measured; CD antigens (a type of leukocyte antigen) can help distinguish cell lineage, and functional subsets including:

  • integrins

  • selectins

  • human leukocyte (HLA) antigens (histocompatibility antigens (glycoproteins)

  • interferons

  • interleukins

  • tumor necrosis factor (TNF)

Concentration and Modification Measurement

Aside from detection, primary antibodies can also be used to measure concentration changes as well as specific modifications such as phosphorylation, methylation, or glycosylation. This allows for the study of proteins which are activated, silenced, processed or causing disease.