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Microarrays & PCR Arrays on ZAGENO

MicroCaster pin conditioner 30 ml Sigma-Aldrich
Molecular Targets / Organism / Product Application /
From $ 83.50 (30 ml)
Sizes 1 (30 ml)
Catalog IDs Z721247-1EA
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MagMAX™-96 for Microarrays Total RNA Isolation Kit Ambion
Molecular Targets mRNA Organism Human, Animals Product Application RNA isolation for microarray
From $ 450.00 (96 Preparations)
Sizes 1 (96 Preparations)
Catalog IDs AM1839
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FAST PAK 2 pad protein array kit Sigma-Aldrich
Molecular Targets Proteins Organism / Product Application Suitable for (ELISA format (sandwich assay) antibody arrays, protein arrays, carbohydrate arrays, reverse phase (micro-Western) arrays using cell or tissue lysates)
From $ 974.30 (1 Kit)
Sizes 1 (1 Kit)
Catalog IDs Z721174-1EA
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SurePrint G3 Human Gene Expression 8x60K v2 Microarray Kit Agilent
Molecular Targets / Organism Human Product Application Detection of low and high expressors for the most biologically relevant data
From $ 5,704.00 (3 slides)
Sizes 1 (3 slides)
Catalog IDs G4851B
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Human Gene Expression 4x44K v2 Microarray Kit Agilent
Molecular Targets / Organism Human Product Application Detection of low and high expressors for the most biologically relevant data
From $ 5,299.00 (5 Slides)
Sizes 1 (5 Slides)
Catalog IDs G4845A
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FAST PAK 16 pad protein array kit Sigma-Aldrich
Molecular Targets Proteins Organism / Product Application Suitable for (ELISA format (sandwich assay) antibody arrays, protein arrays, carbohydrate arrays, reverse phase (micro-Western) arrays using cell or tissue lysates)
From $ 1,043.80 (1 Kit)
Sizes 1 (1 Kit)
Catalog IDs Z721190-1EA
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Human TGF beta Pathway Phosphorylation Array C3 RayBiotech
Molecular Targets Proteins Organism Human Product Application Multiplexed Protein Detection; Detection of Relative Protein Expression; Detecting Patterns of Cytokine Expression; Biomarker/ Key Factor Screening; Identifying Key Factors; Confirming a Biological Process
From $ 481.80 (8 Kits)
Sizes 1 (8 Kits)
Catalog IDs AAH-TGFB-1-8
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Mouse Cytokine Array G5 RayBiotech
Molecular Targets Proteins Organism Vertebrates Product Application Multiplexed Protein Detection; Detection of Relative Protein Expression; Detecting Patterns of Cytokine Expression; Biomarker Screening; Identifying Key Factors; Confirming a Biological Process; Detecting Nephrotoxicity
From $ 519.00 (4 Kits)
Sizes 2 (4 - 8 Kits)
Catalog IDs AAM-CYT-G5-4, AAM-CYT-G5-8
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Rat AKI Array G1 RayBiotech
Molecular Targets Proteins Organism Vertebrates Product Application Multiplexed Protein Detection; Detection of Relative Protein Expression; Detecting Patterns of Cytokine Expression; Biomarker Screening; Identifying Key Factors; Confirming a Biological Process; Detecting Nephrotoxicity
From $ 369.00 (4 Kits)
Sizes 2 (4 - 8 Kits)
Catalog IDs AAR-AKI-G1-4, AAR-AKI-G1-8
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Human Cytokine Array GS9000 RayBiotech
Molecular Targets Proteins Organism Human Product Application Multiplexed Protein Detection; Detection of Relative Protein Expression; Detecting Patterns of Cytokine Expression; Biomarker Screening; Identifying Key Factors; Confirming a Biological Process
From $ 9,270.00 (16 Kits)
Sizes 3 (16 - 64 Kits)
Catalog IDs GSH-CAA-9000-1, GSH-CAA-9000-2, ...
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Human Inflammation Array Q2 RayBiotech
Molecular Targets Proteins Organism Human Product Application Multiplexed Protein Detection; Biomarker Screening; Identifying Key Factors; Confirming Biological Process; Biomarker Validation; Validation of Antibody Array Results; Quantitative Protein Detection; Establishing Normal Range
From $ 194.00 (8 Kits)
Sizes 3 (8 - 50 Kits)
Catalog IDs QAH-INF-2-1, QAH-INF-2-2, ...
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Mouse Cytokine Array GS4000 RayBiotech
Molecular Targets Proteins Organism Vertebrates Product Application Multiplexed Protein Detection; Detection of Relative Protein Expression; Detecting Patterns of Cytokine Expression; Biomarker Screening; Identifying Key Factors; Confirming a Biological Process
From $ 5,562.00 (16 Kits)
Sizes 3 (16 - 64 Kits)
Catalog IDs GSM-CAA-4000-1, GSM-CAA-4000-2, ...
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Microarray Technology

Microarrays are lab-on-chip devices which allow scientists to investigate the expression of thousands of genes in multiple samples simultaneously. The chip is mainly composed of glass, silicon or plastics. On the surface of chip thousands of spots are arrayed, and each spot contains multiple copies of DNA sequences which correspond to a particular gene. One of the applications of microarrays is to allow us to compare expression of various genes in different samples, making microarrays a powerful tool in Detection techniques and life science research.

Applications of microarrays

Tumor formation involves changes of numerous genes, and a DNA (cDNA) microarray can provide a platform which allows medical scientists to have a better understanding of gene expression in different clinical samples. Some types of cancer such as breast cancer are highly heterogeneous containing various molecular and clinical subtypes.

Different clinical subtypes of cancer can show different prognosis to the same treatment due to variation in gene expression. However, exactly how cancer heterogeneity affects prognosis and treatment response of patients has yet to be fully understood. Nonetheless, DNA microarray technologies provide medical scientists an opportunity to analyze and compare expression profile of different cancer clinical/molecular subtypes. By comparing gene expression profiles between samples from different cancer subtypes and normal tissues using microarray technologies, scientists can identify specific genes that are expressed/silenced in each molecular subtype of cancer and scientists can understand how particular genes affect treatment response. Ultimately, scientists can use this technology to identify putative drug targets for cancer treatment.

How to perform a DNA microarray analysis

Multiple preparation steps are required to perform a successful DNA microarray for comparing genes expression in different samples.

Firstly, mRNA must be purified from both experimental sample (e.g., cancer cells) and referee sample (e.g., normal healthy cells) by using an organic solvent. Secondly, mRNA from experimental and referee sample are converted to complementary DNA (cDNA) by reverse transcriptase, and fluorescent probes of different colors are used to label the cDNA samples.

The color of fluorescent probes used in experimental and referee samples should be different (e.g., green fluorescent for referee sample and red fluorescent for experimental sample). Afterward, cDNA from the two samples (from cancer and healthy cells) are added onto the microarray chip. cDNA from the samples hybridize to the complementary strand on the microarray so that each spot on the microarray contains a specific nucleotide sequence which represents a particular gene. The microarray will then be washed to wash off excess cDNA that did not hybridize to the complementary strand. Finally, the microarray will be analyzed in a scanner (exposed to laser) to examine fluorescent of every single spot for red and green. The results of red and green fluorescent will be merged.

What does the result of DNA microarray means?

The fluorescence intensity is positively correlated to the amount of cDNA from each sample. The appearance of red fluorescence in a spot means the gene is highly expressed in experimental sample (e.g., tumor cells) while the appearance of green fluorescence in a spot means the gene is actively expressed in referee sample (healthy cells). For a gene that is highly expressed in both the experimental and referee samples, the spot will be yellow in color when exposed to the laser.

Protein microarray

One of the limitations of DNA microarrays is that expression of mRNA is not fully correlated to protein expression profile of organisms. Therefore, protein microarrays have been developed to examine and compare protein expression profiles of different samples. The principle of DNA and protein microarrays is similar, but antibodies are used to capture/hybridize with target proteins in protein microarray.

Compare Protein Microarrays for Cancer Screening

With our compare function, you can avoid all the time and energy wasted sifting through multiple web pages from different suppliers. At ZAGENO you can clearly see kits side-by-side, with the relevant attributes for each kit neatly in line for easy selection of the best product for you.

The ZAGENO comparison does not highlight one kit to be better than the other, as the kit of choice may vary between researchers - depending on each individual's preferred attributes. The best kit is the one that meets your needs - ZAGENO allows you to make an informed decision with minimum effort.

Check out our How It Works page for a guide to using the comparison function.

Problems in the lab? Learn about methods and experiments in our Knowledge section or look up a specific Troubleshooting guide.

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