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Amino Acids

AccQ-Tag Ultra Eluent B

Waters

From
$ 193.60 (950 ml)
Sizes
1 (950 ml)
Catalog IDs
186003839
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Amino Acids

Fmoc-Lys(Boc)-2-Cl-Trt resin

Advanced ChemTech

Purity
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CAS Number
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From
$ 75.00 (1 g)
Sizes
3 (1 - 25 g)
Catalog IDs
SK5990-1g, SK5990-5g, ...
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Amino Acids

L-Glutamic Acid

AMRESCO

From
$ 44.65 (1 kg)
Sizes
1 (1 kg)
Catalog IDs
0421-1KG
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Amino Acids

L-Glutamine SKU: 0374

AMRESCO

From
$ 121.86 (500 g)
Sizes
2 (1 - 500 kg)
Catalog IDs
0374-1KG, 0374-500G
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Amino Acids

Fmoc-Aib-OH

P3 Biosystems

Purity
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CAS Number
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Molecular Weight
325.36
325.36
From
$ 10.00 (1 g)
Sizes
4 (1 - 50 g)
Catalog IDs
47012-1g, 47012-5g, ...
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Amino Acids

Urea ReagentPlus®, ≥99.5%, pellets

Sigma-Aldrich

Purity
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CAS Number
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From
$ 119.94 (5 kg)
Sizes
1 (5 kg)
Catalog IDs
U1250-5KG
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Amino Acids

D-Homoserine SKU : h4021

Sigma-Aldrich

Purity
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CAS Number
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From
$ 134.00 (250 mg)
Sizes
2 (1 - 250 g)
Catalog IDs
H4021-1G, H4021-250MG
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Amino Acids

DL-Homocysteine SKU : h4628

Sigma-Aldrich

Purity
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CAS Number
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Molecular Weight
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From
$ 22.25 (10 mg)
Sizes
4 (1 - 25 g)
Catalog IDs
H4628-1G, H4628-5G, ...
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Amino Acids

Hypotaurine SKU : h1384

Sigma-Aldrich

Purity
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CAS Number
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Molecular Weight
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From
$ 19.80 (10 mg)
Sizes
4 (1 - 250 g)
Catalog IDs
H1384-1G, H1384-10MG, ...
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Amino Acids

N-(4-Hydroxyphenyl)glycine SKU : h51507

Sigma-Aldrich

Purity
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CAS Number
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Molecular Weight
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From
$ 45.50 (5 g)
Sizes
1 (5 g)
Catalog IDs
H51507-5G
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Amino Acids

Ro 25-6981 hydrochloride hydrate SKU : R7150

Sigma-Aldrich

Purity
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CAS Number
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Molecular Weight
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From
$ 135.00 (5 mg)
Sizes
2 (5 - 25 mg)
Catalog IDs
r7150-5MG, r7150-25MG
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Amino Acids

Selenocystamine dihydrochloride SKU : S0520

Sigma-Aldrich

Purity
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CAS Number
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Molecular Weight
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From
$ 74.00 (25 mg)
Sizes
2 (25 - 100 mg)
Catalog IDs
s0520-25MG, s0520-100MG
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Amino Acid Functions

Amino acids are organic molecules comprised mainly of carbon, hydrogen, oxygen, and nitrogen. They contain a side chain (R group), which is specific for each amino acid, in addition to an amine (-NH2) and a carboxyl (-COOH) functional group. Around 500 amino acids are known, whereas only 20 are coded by the DNA. For humans nine amino acids like Histidine or Lysine are essential, meaning they cannot be produced by the body itself and have to be taken up with food.

In vivo, amino acids are the building blocks of peptides and proteins. Through translation of RNA amino acids are attached step-by-step with each other. The sequence for these polymer chains is encoded by the DNA which is then transcribed into RNA followed by the translation into proteins.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Peptide Bond Formation

The peptide bond is formed by the reaction of the carboxyl group with the amino group of the following amino acid resulting in an amide bond. In most cases the in vivo polymerization is catalyzed by ribosomes together with different other molecules like transfer RNA (tRNA) – which carry the next amino acid –, initiation factors, elongation factors and termination factors. tRNAs are linked with only one specific amino acid through an ester bond by enzymes called aminoacyl tRNA synthetases. The right sequence of the proteins is achieved by complementary base pairing of the loaded tRNAs with the mRNA situated in the ribosomes. The genetic code is defined by codons, a sequence of three DNA bases which code for one amino acid. Since the genetic code has redundancy but no ambiguity, there are codons translate into the same amino acid but no codon that can translate into two different amino acids.

Structure

All proteinogenic amino acids belong to the group of α-amino acids – the amine and carboxyl group are attached to the first (alpha-) carbon atom – and occur in two chiral forms, called L- or D-isomer. Most proteins are composed of L-amino acids, but rarely enzymatic posttranslational modifications can produce proteins with D-amino acids.

In terms of proteins, the amino acid sequence is called primary structure. Along with posttranslational modifications, the primary structure determines the secondary and the tertiary structure of a protein.

Applications

Beside the use in protein synthesis, amino acids can exert non-protein functions. Through oxidation to urea and carbon dioxide, they may be converted into energy. The synthesis of neurotransmitters like gamma-amino-butyric acid (GABA) and other molecules require amino acids as precursors.

Labeling of amino acids is widely used in the field of proteomics, e.g. in SILAC (stable isotope labeling by amino acids in cell culture) experiments. You have the choice between various labeling techniques like radioactive isotope, non-radioactive isotope or dye labeling.

In the industry animal feed is complemented with amino acids to compensate the absence of essential amino acids in the bulk components.

Glutamic acid is often used as a flavor enhancer, and aspartame as a low-calorie sugar replacement.