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Growth Factors on ZAGENO

EX-CELL® Advanced™ CHO Feed 1 (with glucose) Sigma-Aldrich
Reagent Type Growth factors Applicable Processes Cultivation Quantity 1 L, 10 L, 50 L
From $ 139.00 (1 L)
Sizes 3 (1 - 50 L)
Catalog IDs 24367C-1L, 24367C-10L, ...
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EGFR (ErbB1) d747-749 A750P Recombinant Human Protein Invitrogen
Reagent Type Growth factors Applicable Processes / Quantity /
From $ 445.00 (10 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs A33734, A33512, ...
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Epidermal Growth Factor, Biotinylated, complexed to Alexa Fluor™ 488 Streptavidin (Alexa Fluor™ 488 EGF complex) Invitrogen
Reagent Type Growth factors Applicable Processes / Quantity /
From $ 371.00 (100 µg)
Sizes 1 (100 µg)
Catalog IDs E13345
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Epidermal Growth Factor, Tetramethylrhodamine Conjugate (rhodamine EGF) Invitrogen
Reagent Type Growth factors Applicable Processes / Quantity /
From $ 355.00 (20 µg)
Sizes 1 (20 µg)
Catalog IDs E3481
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R3 IGF-1 human Sigma-Aldrich
Reagent Type Growth factors Applicable Processes Cultivation Quantity /
From $ 298.00 (100 µg)
Sizes 1 (100 µg)
Catalog IDs I1146-.1MG
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EGFR (ErbB1) T790M C797S L858R Recombinant Human Protein Invitrogen
Reagent Type Growth factors Applicable Processes / Quantity /
From $ 398.00 (10 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs A33725, A33502, ...
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Recombinant human TNF-α Invivogen
Reagent Type / Applicable Processes / Quantity /
From $ 170.00 (20 µg)
Sizes 1 (20 µg)
Catalog IDs rcyc-htnfa
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Brassinolide SKU : 10032 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 48.00 (5 mg)
Sizes 2 (5 - 10 mg)
Catalog IDs 10032-1, 10032-2
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Brassinolide [10mM] SKU : 10032 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 98.00 (1 ml)
Sizes 1 (1 ml)
Catalog IDs 10032
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Sodium Pyruvate (100 mM) Thermo Fisher Scientific
Reagent Type Growth factors Applicable Processes Cultivation Quantity /
From $ 10.09 (100 ml)
Sizes 2 (100 ml)
Catalog IDs 11360070, 11360039
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N2 NeuroPlex™ Serum-Free Supplement Gemini Bio-Products
Reagent Type Growth factors, Growth media Applicable Processes Cultivation Quantity 5ml
From $ 62.00 (5 ml)
Sizes 1 (5 ml)
Catalog IDs 400-163
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Leibovitz's L-15 Medium, no phenol red Gibco
Reagent Type / Applicable Processes / Quantity /
From $ 48.14 (500 mL)
Sizes 1 (500 mL)
Catalog IDs 21083027
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Recombinant Human IL-7 PeproTech
Reagent Type Growth factors Applicable Processes Expression, Induction Quantity 10 µg
From $ 80.00 (2 µg)
Sizes 7 (2 - 1000 µg)
Catalog IDs 200-07-2, 200-07-10, ...
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Insulin-like Growth Factor-I human Sigma-Aldrich
Reagent Type Growth factors Applicable Processes Cultivation, Induction, Inhibition Quantity 50 µg
From $ 227.50 (50 µg)
Sizes 1 (50 µg)
Catalog IDs I3769-50UG
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Human FGF10 Protein (Recombinant) LSBio
Reagent Type Growth factors Applicable Processes / Quantity 5 µg, 25 µg
From $ 225.00 (5 µg)
Sizes 2 (5 - 25 µg)
Catalog IDs LS-G3620-5, LS-G3620-25
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Growth Factor Function

Growth factors act as signaling molecules between cells. The signaling may occur between local cells (paracrine signaling), between distant cells (endocrine signaling) or the same cell that produced the signal binds its “own” growth factor (autocrine signaling). To induce the signal cascade, growth factors bind to their specific receptor situated on the cell membrane or, in the case of the fat-soluble steroid hormones, inside of the cell. Growth factors often target receptors of the tyrosine kinase family followed by downstream signaling transduction pathways like the MAP kinase signaling cascade.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Growth Factor Stimulation

Growth factors are important for the regulation of many different cellular processes. Usually, they are naturally occurring proteins or steroid hormones and are capable of stimulating:

• cell growth

• proliferation

• tissue repair

• cellular differentiation

• cell survival

• inflammation

There are many different growth factors which are often grouped into families like the Transforming Growth Factor (TGF) family or the family of Interleukins (IL).

Applications In Vivo and In Vitro

In vivo, many cells require the presence of different growth factors to proliferate or differentiate and to maintain their viability. In in vitro cell cultures, some cell lines require the addition of growth factors to the culture medium in order to proliferate. Additionally, they could be used to stimulate differentiation of cell lines.

In the clinic, growth factors may be utilized in the treatment of different diseases. For example, neutropenia may be treated with hematopoietic growth factors (granulocyte-colony stimulating factor (G-CSF)).

Available growth factors are often produced by genetic engineering. Therefore, recombinant bacteria, which have the particular genes inserted and are able to transcribe these genes as well as to translate the mRNA into the corresponding proteins, are produced. After protein extraction and purification, the growth factors are ready to be used in your experiments.