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Growth Factors on ZAGENO

Recombinant Human EGF Applied Biological Materials
From $ 20.00 (50 µg)
Sizes 3 (1 - 500 mg)
Catalog IDs Z100139, Z100131, ...
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Recombinant Human Thymosin-Beta 4 (TMSB4X) Applied Biological Materials
From $ 40.00 (20 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs Z102009, Z102005, ...
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Recombinant Human EPO Applied Biological Materials
From $ 60.00 (50 µg)
Sizes 2 (1 - 50 mg)
Catalog IDs Z101439, Z101435
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Recombinant Human IGF1 Applied Biological Materials
From $ 60.00 (100 µg)
Sizes 2 (1 - 100 mg)
Catalog IDs Z100389, Z100385
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Recombinant Human TWEAK (TNFSF12) Applied Biological Materials
From $ 60.00 (25 µg)
Sizes 2 (25 - 500 µg)
Catalog IDs Z102275, Z102279
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Recombinant Human Leptin (LEP) Applied Biological Materials
From $ 65.00 (200 µg)
Sizes 3 (1 - 200 mg)
Catalog IDs Z101857, Z101859, ...
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Recombinant Human FGF8 Applied Biological Materials
From $ 70.00 (50 µg)
Sizes 2 (1 - 50 mg)
Catalog IDs Z101709, Z101705
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Recombinant Human GMFB Applied Biological Materials
From $ 70.00 (10 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs Z101119, Z101115, ...
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Recombinant Human IFNA2 Applied Biological Materials
From $ 70.00 (100 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs Z101587, Z101589, ...
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Recombinant Human IL11 Applied Biological Materials
From $ 70.00 (10 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs Z100429, Z100425, ...
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Recombinant Human IL18 Applied Biological Materials
From $ 70.00 (25 µg)
Sizes 3 (1 - 100 mg)
Catalog IDs Z100479, Z100475, ...
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Recombinant Human IL3 Applied Biological Materials
From $ 70.00 (10 µg)
Sizes 3 (1 - 50 mg)
Catalog IDs Z100519, Z100515, ...
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Growth Factor Function

Growth factors act as signaling molecules between cells. The signaling may occur between local cells (paracrine signaling), between distant cells (endocrine signaling) or the same cell that produced the signal binds its “own” growth factor (autocrine signaling). To induce the signal cascade, growth factors bind to their specific receptor situated on the cell membrane or, in the case of the fat-soluble steroid hormones, inside of the cell. Growth factors often target receptors of the tyrosine kinase family followed by downstream signaling transduction pathways like the MAP kinase signaling cascade.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Growth Factor Stimulation

Growth factors are important for the regulation of many different cellular processes. Usually, they are naturally occurring proteins or steroid hormones and are capable of stimulating:

• cell growth

• proliferation

• tissue repair

• cellular differentiation

• cell survival

• inflammation

There are many different growth factors which are often grouped into families like the Transforming Growth Factor (TGF) family or the family of Interleukins (IL).

Applications In Vivo and In Vitro

In vivo, many cells require the presence of different growth factors to proliferate or differentiate and to maintain their viability. In in vitro cell cultures, some cell lines require the addition of growth factors to the culture medium in order to proliferate. Additionally, they could be used to stimulate differentiation of cell lines.

In the clinic, growth factors may be utilized in the treatment of different diseases. For example, neutropenia may be treated with hematopoietic growth factors (granulocyte-colony stimulating factor (G-CSF)).

Available growth factors are often produced by genetic engineering. Therefore, recombinant bacteria, which have the particular genes inserted and are able to transcribe these genes as well as to translate the mRNA into the corresponding proteins, are produced. After protein extraction and purification, the growth factors are ready to be used in your experiments.