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Channel Blockers

Lomerizine dihydrochloride SKU : L6295

Sigma-Aldrich

Molecular Formula
/
/
Molecular Weight
/
/
CAS Number
/
/
From
$ 75.50 (10 mg)
Sizes
2 (10 - 50 mg)
Catalog IDs
L6295-10MG, L6295-50MG
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Channel Blockers

R(+)-IAA-94 SKU : I117

Sigma-Aldrich

Molecular Formula
/
/
Molecular Weight
/
/
CAS Number
/
/
From
$ 147.00 (10 mg)
Sizes
3 (10 - 250 mg)
Catalog IDs
I117-10MG-I, I117-50MG-I, ...
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Channel Blockers

L-Aspartic acid

Tocris

Molecular Formula
C4H7NO4
C4H7NO4
Molecular Weight
133.1
133.1
CAS Number
56-84-8
56-84-8
From
$ 59.00 (1 g)
Sizes
1 (1 g)
Catalog IDs
0214/1G
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Channel Blockers

Taurine

Tocris

Molecular Formula
C2H7NO3S
C2H7NO3S
Molecular Weight
125.14
125.14
CAS Number
107-35-7
107-35-7
From
$ 59.00 (1 g)
Sizes
1 (1 g)
Catalog IDs
0209/1G
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Channel Blockers

(-)-Nicotine ditartrate

Tocris

Molecular Formula
C10H14N2·2C4H6O6
C10H14N2·2C4H6O6
Molecular Weight
462.41
462.41
CAS Number
65-31-6
65-31-6
From
$ 69.00 (50 mg)
Sizes
1 (50 mg)
Catalog IDs
3546/50
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Channel Blockers

1-Phenylbiguanide hydrochloride

Tocris

Molecular Formula
C8H11N5·HCl
C8H11N5·HCl
Molecular Weight
213.67
213.67
CAS Number
55-57-2
55-57-2
From
$ 69.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0969/100
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Channel Blockers

Glibenclamide

Tocris

Molecular Formula
C23H28ClN3O5S
C23H28ClN3O5S
Molecular Weight
494.0
494.0
CAS Number
10238-21-8
10238-21-8
From
$ 69.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0911/100
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Channel Blockers

(-)-Cotinine

Tocris

Molecular Formula
C10H12N2O
C10H12N2O
Molecular Weight
176.22
176.22
CAS Number
486-56-6
486-56-6
From
$ 79.00 (50 mg)
Sizes
1 (50 mg)
Catalog IDs
3110/50
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Channel Blockers

4-Aminopyridine

Tocris

Molecular Formula
C5H6N2
C5H6N2
Molecular Weight
94.12
94.12
CAS Number
504-24-5
504-24-5
From
$ 79.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0940/100
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Channel Blockers

9-AC

Tocris

Molecular Formula
C15H10O2
C15H10O2
Molecular Weight
222.24
222.24
CAS Number
723-62-6
723-62-6
From
$ 79.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0963/100
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Channel Blockers

Dantrolene, sodium salt

Tocris

Molecular Formula
C14H9N4NaO5
C14H9N4NaO5
Molecular Weight
336.23
336.23
CAS Number
14663-23-1
14663-23-1
From
$ 79.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0507/100
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Channel Blockers

Primidone

Tocris

Molecular Formula
C12H14N2O2
C12H14N2O2
Molecular Weight
218.25
218.25
CAS Number
125-33-7
125-33-7
From
$ 79.00 (100 mg)
Sizes
1 (100 mg)
Catalog IDs
0830/100
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Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection