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Channel Blockers
GYKI 52466 SKU: HB0311
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (10 mg)
Available From
1 Vendor
Price
$ 107.00
Catalog IDs
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Channel Blockers
Ibotenic acid SKU: HB0330
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (1 - 5 mg)
Available From
1 Vendor
Price Range
$ 57.00 - $ 199.00
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Channel Blockers
L-Quisqualic acid SKU: HB0387
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (5 mg)
Available From
1 Vendor
Price
$ 132.00
Catalog IDs
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Channel Blockers
VU 0364770 SKU: HB0640
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 463.00
Catalog IDs
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Channel Blockers
AP 18 SKU: HB1157
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (25 mg)
Available From
1 Vendor
Price
$ 232.00
Catalog IDs
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Channel Blockers
BCTC SKU: HB1190
Scientific Score
2.83
Brand
Hello Bio
Sizes
3 (5 - 50 mg)
Available From
1 Vendor
Price Range
$ 67.00 - $ 396.00
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Channel Blockers
MDCPG SKU: HB1602
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 181.00 - $ 764.00
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Channel Blockers
2-[1-(4-Piperonyl)piperazinyl]benzothiazole SKU: HB1631
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (5 mg)
Available From
1 Vendor
Price
$ 57.00
Catalog IDs
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Channel Blockers
SCH 23390 hydrochloride SKU: HB1643
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 107.00 - $ 407.00
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Channel Blockers
(RS)-(±)-Sulpiride SKU: HB1835
Scientific Score
1.46
Brand
Hello Bio
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 30.00
Catalog IDs
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Channel Blockers
PPADS tetrasodium salt SKU: HB1950
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 64.00 - $ 223.00
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Channel Blockers
α-Bungarotoxin SKU: HB2038
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (1 mg)
Available From
1 Vendor
Price
$ 140.00
Catalog IDs
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Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

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Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection