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Chelators
Ammonium Chloride-EDTA Solution SKU: 626
Chemical Name
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/
CAS Number
12125-02-9, 1336-21-6, 7732-18-5
12125-02-9, 1336-21-6, 7732-18-5
Purity
/
/
Scientific Score
3.25
Brand
RICCA
Sizes
3 (1 - 500 L)
Available From
2 Vendors
Price Range
$ 48.45 - $ 153.68
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Chelators
EGTA
Chemical Name
/
/
CAS Number
67-42-5
67-42-5
Purity
>98%
>98%
Scientific Score
8.08
Brand
Tocris
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 49.00
Catalog IDs
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Chelators
EDTA 50% W/V
Chemical Name
/
/
CAS Number
6381-92-6, 7732-18-5, 1310-73-2
6381-92-6, 7732-18-5, 1310-73-2
Purity
50% (w/v)
50% (w/v)
Scientific Score
9.58
Brand
LabChem
Sizes
2 (1 - 500 L)
Available From
3 Vendors
Price Range
$ 65.34 - $ 125.30
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Chelators
EDTA TITRANT, 0.01M (0.02N)
Chemical Name
/
/
CAS Number
7732-18-5, 6381-92-6
7732-18-5, 6381-92-6
Purity
/
/
Scientific Score
9.64
Brand
LabChem
Sizes
4 (4 - 500 L)
Available From
3 Vendors
Price Range
$ 15.30 - $ 136.55
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Chelators
EDTA, 0.1M (0.2N)
Chemical Name
/
/
CAS Number
7732-18-5, 6381-92-6
7732-18-5, 6381-92-6
Purity
/
/
Scientific Score
9.74
Brand
LabChem
Sizes
5 (1 - 500 L)
Available From
3 Vendors
Price Range
$ 26.29 - $ 535.25
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Chelators
MAGNESIUM EDTA 0.02% W/V
Chemical Name
/
/
CAS Number
7732-18-5, 14402-88-1
7732-18-5, 14402-88-1
Purity
0.02% (w/v)
0.02% (w/v)
Scientific Score
9.19
Brand
LabChem
Sizes
2 (1 - 500 L)
Available From
3 Vendors
Price Range
$ 29.73 - $ 53.35
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Chelators
Nitrilotriacetic acid SKU : 72559
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
9.48
Brand
Sigma-Aldrich
Sizes
2 (100 - 500 g)
Available From
2 Vendors
Price Range
$ 61.50 - $ 238.00
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Chelators
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate SKU : 75058
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
6.51
Brand
Sigma-Aldrich
Sizes
1 (100 mg)
Available From
2 Vendors
Price Range
$ 265.50 - $ 336.70
Catalog IDs
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Chelators
(2-Hydroxypropyl)-γ-cyclodextrin SKU : 779113
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
9.25
Brand
Sigma-Aldrich
Sizes
2 (100 - 500 g)
Available From
1 Vendor
Price
$ 426.50
Catalog IDs
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Chelators
Methyl-β-cyclodextrin SKU : 779873
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
9.61
Brand
Sigma-Aldrich
Sizes
5 (25 - 10000 kg)
Available From
2 Vendors
Price Range
$ 592.00 - $ 12,288.75
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Chelators
(−)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid SKU : 560111
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
7.76
Brand
Sigma-Aldrich
Sizes
2 (25 - 100 mg)
Available From
2 Vendors
Price Range
$ 165.50 - $ 644.61
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Chelators
(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid SKU : 442666
Chemical Name
/
/
CAS Number
/
/
Purity
/
/
Scientific Score
7.34
Brand
Sigma-Aldrich
Sizes
2 (25 - 100 mg)
Available From
2 Vendors
Price Range
$ 269.50 - $ 936.45
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Chelator Function and Structure

Chelators or chelating agents are small water-soluble molecules which form complexes with metal ions and are occasionally fluorescent. As a complex (chelate) they are inert in solution; requiring high energy for dissociation. However, metal exchange is possible in labile complexes. Sequestering agents represent chelators which produce soluble metal complexes.

The functional groups of chelators are two of =O, -NH2 or -COO-. These are groups which donate an electron pair to the metal ion to form the complex and must be positioned correctly to allow ring formation. Chelators represent a major component of cellular metabolism.

Popular chelators include EDTA and Deferoxamine Mesylate.

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Chelator Classifications

Natural Chelators (can aid in physiological systems transport iron and oxygen) include:

• Phosphates

• Ferrioxamines

• Phenolics

• Ionophores (monensin, valinomycin, gramicidin)

• Tetrapyrrols

Synthetic Chelators (suitable for separating metals in solutions) include:

• ionophores Nitrilotriacetic acid, NTA ortho-Phenanthroline

• 2,2'-Bipyridyl

• Salicylic acid

• Dimercaptopropanol

• Triethanolamine, TEA

• Ethylene glycol-bis-(2-aminoethyl)-N,N,N', N'-tetraacetic acid (EGTA)

• Ethylenediaminotetraacetic acid, EDTA Ethylenedioxy-diethylene-dinitrilo-tetraacetic acid

Chelator Applications

• Animal food addition to prevent precipitation or absorption of essential metals

• Elution in chelation affinity chromatography (EDTA or EGTA)

• Reduce metal interference when using metal indicators for measuring intracellular cation concentration (Ca2+ in FURA or QUIN).

• Reagent in quantitative complexometric determination of metals

• Removal of complex inhibitory heavy metals from buffer solutions

• Nutrient solution component for microorganisms/plants in hydroculture

Calcium Chelators

Calcium chelators have a high affinity for calcium ions through carboxylic groups. Binding can be affected by pH, other ions, and coordination to other proteins.

Calcium buffers are produced with the help of BAPTA. The chelator can also be used study calcium cell signaling by controlling cytosolic calcium concentration.

General calcium chelator use:

• Controlling Ca2+ levels intracellularly and extracellularly

• NMR analysis of Ca2+

• Research into calcium shuttling, mobilization and spatial calcium buffering