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Chelators

Ethylenediaminetetraacetic acid solution SKU: E8008

Sigma-Aldrich

Chemical Name
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/
CAS Number
/
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Purity
/
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From
$ 14.70 (100 ml)
Sizes
1 (100 ml)
Catalog IDs
E8008-100ML
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Chelators

EDTA 0.5 M Sterile Solution pH 8.0 SKU: E177

AMRESCO

From
$ 29.67 (100 ml)
Sizes
2 (100 - 500 ml)
Catalog IDs
E177-100ML, E177-500ML
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Chelators

EDTA Disodium Dihydrate SKU: M101

AMRESCO

From
$ 64.10 (500 g)
Sizes
3 (1 - 500 kg)
Catalog IDs
M101-1KG, M101-2.5KG, ...
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Chelators

Silica gel C18 on TLC Plates SKU : Z292923

Sigma-Aldrich

Chemical Name
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CAS Number
/
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Purity
/
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From
$ 642.00 (50 Units)
Sizes
1 (50 Units)
Catalog IDs
Z292923-1PAK
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Chelators

Ferrous sulfate chelate solution SKU : f0518

Sigma-Aldrich

Chemical Name
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/
CAS Number
/
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Purity
/
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From
$ 32.25 (1 L)
Sizes
1 (1 L)
Catalog IDs
F0518-1L
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Chelators

Ethylenediaminetetraacetic acid dipotassium salt dihydrate SKU : ed2p

Sigma-Aldrich

Chemical Name
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CAS Number
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Purity
/
/
From
$ 51.06 (100 g)
Sizes
3 (1 - 500 kg)
Catalog IDs
ED2P-1KG, ED2P-100G, ...
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Chelators

EGTA

Tocris

Chemical Name
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CAS Number
67-42-5
67-42-5
Purity
>98%
>98%
From
$ 49.00 (1 g)
Sizes
1 (1 g)
Catalog IDs
2807/1G
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Chelators

Ethylenediaminetetraacetic acid dipotassium salt dihydrate SKU : 03659

Sigma-Aldrich

Chemical Name
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CAS Number
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Purity
/
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From
$ 87.00 (100 g)
Sizes
2 (100 - 500 g)
Catalog IDs
03659-100G, 03659-500G
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Chelators

Ethylenediaminetetraacetic acid tripotassium salt dihydrate SKU : 03664

Sigma-Aldrich

Chemical Name
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CAS Number
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/
Purity
/
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From
$ 140.00 (100 g)
Sizes
2 (100 - 500 g)
Catalog IDs
03664-100G, 03664-500G
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Chelators

(−)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid SKU : 560111

Sigma-Aldrich

Chemical Name
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CAS Number
/
/
Purity
/
/
From
$ 165.50 (25 mg)
Sizes
2 (25 - 100 mg)
Catalog IDs
560111-25MG, 560111-100MG
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Chelators

(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid SKU : 442666

Sigma-Aldrich

Chemical Name
/
/
CAS Number
/
/
Purity
/
/
From
$ 269.50 (25 mg)
Sizes
2 (25 - 100 mg)
Catalog IDs
442666-25MG-A, 442666-100MG-A
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Chelators

Ethylenediaminetetraacetic acid SKU : 431788

Sigma-Aldrich

Chemical Name
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/
CAS Number
/
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Purity
/
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From
$ 129.00 (100 g)
Sizes
1 (100 g)
Catalog IDs
431788-100G
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Chelator Function and Structure

Chelators or chelating agents are small water-soluble molecules which form complexes with metal ions and are occasionally fluorescent. As a complex (chelate) they are inert in solution; requiring high energy for dissociation. However, metal exchange is possible in labile complexes. Sequestering agents represent chelators which produce soluble metal complexes.

The functional groups of chelators are two of =O, -NH2 or -COO-. These are groups which donate an electron pair to the metal ion to form the complex and must be positioned correctly to allow ring formation. Chelators represent a major component of cellular metabolism.

Popular chelators include EDTA and Deferoxamine Mesylate.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Chelator Classifications

Natural Chelators (can aid in physiological systems transport iron and oxygen) include:

• Phosphates

• Ferrioxamines

• Phenolics

• Ionophores (monensin, valinomycin, gramicidin)

• Tetrapyrrols

Synthetic Chelators (suitable for separating metals in solutions) include:

• ionophores Nitrilotriacetic acid, NTA ortho-Phenanthroline

• 2,2'-Bipyridyl

• Salicylic acid

• Dimercaptopropanol

• Triethanolamine, TEA

• Ethylene glycol-bis-(2-aminoethyl)-N,N,N', N'-tetraacetic acid (EGTA)

• Ethylenediaminotetraacetic acid, EDTA Ethylenedioxy-diethylene-dinitrilo-tetraacetic acid

Chelator Applications

• Animal food addition to prevent precipitation or absorption of essential metals

• Elution in chelation affinity chromatography (EDTA or EGTA)

• Reduce metal interference when using metal indicators for measuring intracellular cation concentration (Ca2+ in FURA or QUIN).

• Reagent in quantitative complexometric determination of metals

• Removal of complex inhibitory heavy metals from buffer solutions

• Nutrient solution component for microorganisms/plants in hydroculture

Calcium Chelators

Calcium chelators have a high affinity for calcium ions through carboxylic groups. Binding can be affected by pH, other ions, and coordination to other proteins.

Calcium buffers are produced with the help of BAPTA. The chelator can also be used study calcium cell signaling by controlling cytosolic calcium concentration.

General calcium chelator use:

• Controlling Ca2+ levels intracellularly and extracellularly

• NMR analysis of Ca2+

• Research into calcium shuttling, mobilization and spatial calcium buffering