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Chelators on ZAGENO

Ethylenediaminetetraacetic acid tetrasodium salt dihydrate Sigma-Aldrich
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From $ 58.36 (100 g)
Sizes 1 (100 g)
Catalog IDs ED4SS-100G
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Ethylenediaminetetraacetic acid iron(III) sodium salt Sigma-Aldrich
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From $ 93.39 (100 g)
Sizes 2 (1 - 100 kg)
Catalog IDs EDFS-1KG, EDFS-100G
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Nickel-IDA Agarose Resin SKU: 10590 Cepham Life Sciences
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From $ 85.10 (5 ml)
Sizes 3 (5 - 25 ml)
Catalog IDs 10590, 10590-1, ...
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Nickel-IDA Agarose Resin, 1ml Column SKU: 10591 Cepham Life Sciences
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From $ 144.95 (5 Columns)
Sizes 1 (5 Columns)
Catalog IDs 10591
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Nickel-NTA Agarose Resin, 1ml Spin Column SKU: 10594 Cepham Life Sciences
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From $ 125.00 (5 Columns)
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Catalog IDs 10594
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Edetate disodium United States Pharmacopeia (USP) Reference Standard Sigma-Aldrich
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From $ 338.10 (200 mg)
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Catalog IDs 1233009-200MG
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Ethylenediaminetetraacetic acid disodium salt dihydrate for electrophoresis, for molecular biology, 99.0-101.0% (titration) Sigma-Aldrich
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From $ 26.08 (50 g)
Sizes 3 (50 - 500 g)
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Ethylenediaminetetraacetic acid dipotassium salt dihydrate SKU : ed2p Sigma-Aldrich
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Sodium citrate tribasic dihydrate SKU : 71409 Sigma-Aldrich
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From $ 140.00 (1 kg)
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Catalog IDs 71409-1KG
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1,4,8,11-Tetraazacyclotetradecane-5,12-dione dihydrate SKU : 728322 Sigma-Aldrich
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Catalog IDs 728322-250MG
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1,7-Diaza-12-crown-4 SKU : 73753 Sigma-Aldrich
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(2-Hydroxypropyl)-γ-cyclodextrin SKU : 779113 Sigma-Aldrich
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From $ 426.50 (100 g)
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Catalog IDs 779113-100G, 779113-500G
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Chelator Function and Structure

Chelators or chelating agents are small water-soluble molecules which form complexes with metal ions and are occasionally fluorescent. As a complex (chelate) they are inert in solution; requiring high energy for dissociation. However, metal exchange is possible in labile complexes. Sequestering agents represent chelators which produce soluble metal complexes.

The functional groups of chelators are two of =O, -NH2 or -COO-. These are groups which donate an electron pair to the metal ion to form the complex and must be positioned correctly to allow ring formation. Chelators represent a major component of cellular metabolism.

Popular chelators include EDTA and Deferoxamine Mesylate.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Chelator Classifications

Natural Chelators (can aid in physiological systems transport iron and oxygen) include:

• Phosphates

• Ferrioxamines

• Phenolics

• Ionophores (monensin, valinomycin, gramicidin)

• Tetrapyrrols

Synthetic Chelators (suitable for separating metals in solutions) include:

• ionophores Nitrilotriacetic acid, NTA ortho-Phenanthroline

• 2,2'-Bipyridyl

• Salicylic acid

• Dimercaptopropanol

• Triethanolamine, TEA

• Ethylene glycol-bis-(2-aminoethyl)-N,N,N', N'-tetraacetic acid (EGTA)

• Ethylenediaminotetraacetic acid, EDTA Ethylenedioxy-diethylene-dinitrilo-tetraacetic acid

Chelator Applications

• Animal food addition to prevent precipitation or absorption of essential metals

• Elution in chelation affinity chromatography (EDTA or EGTA)

• Reduce metal interference when using metal indicators for measuring intracellular cation concentration (Ca2+ in FURA or QUIN).

• Reagent in quantitative complexometric determination of metals

• Removal of complex inhibitory heavy metals from buffer solutions

• Nutrient solution component for microorganisms/plants in hydroculture

Calcium Chelators

Calcium chelators have a high affinity for calcium ions through carboxylic groups. Binding can be affected by pH, other ions, and coordination to other proteins.

Calcium buffers are produced with the help of BAPTA. The chelator can also be used study calcium cell signaling by controlling cytosolic calcium concentration.

General calcium chelator use:

• Controlling Ca2+ levels intracellularly and extracellularly

• NMR analysis of Ca2+

• Research into calcium shuttling, mobilization and spatial calcium buffering