Experience more EUREKA moments
Results: 1-12 of 100+ products
Sort by:
Show as:

Inhibitors on ZAGENO

HDAC1 Inhibitor Screening Assay Kit SKU: 10011564 Cayman Chemical
From $ 352.50 (1 Unit)
Sizes 1 (1 Unit)
Catalog IDs 10011564-96
Added to comparison view - remove
View Product
Protease Inhibitor Cocktail SKU: 22020002 bio-World
From $ 69.22 (1 ml)
Sizes 2 (1 - 5 ml)
Catalog IDs 22020002-1, 22020002-2
Added to comparison view - remove
View Product
Protease Inhibitor Cocktail V animal f SKU: 22020011 bio-World
From $ 66.21 (1 Vial)
Sizes 1 (1 Vial)
Catalog IDs 22020011-1
Added to comparison view - remove
View Product
Pail Inhibitory Mold Agar BD
From $ 884.70 (1 Unit)
Sizes 1 (1 Unit)
Catalog IDs 212254
Added to comparison view - remove
View Product
N-Ethylmaleimide SKU : 04259 Sigma-Aldrich
Applicable Processes /
From $ 116.00 (5 g)
Sizes 1 (5 g)
Catalog IDs 04259-5G
Added to comparison view - remove
View Product
FDI 6 - NCGC 00099374 Axon Medchem
From $ 118.00 (10 mg)
Sizes 2 (10 - 50 mg)
Catalog IDs 2384-10MG, 2384-50MG
Added to comparison view - remove
View Product
cOmplete™ ULTRA Tablets, glass vials Protease Inhibitor Cocktail Roche Life Science
Applicable Processes Inhibition, Purification
From $ 365.00 (20 Tablets)
Sizes 2 (20 - 60 Tablets)
Catalog IDs 5892988001, 6538304001
Added to comparison view - remove
View Product
cOmplete™, Mini, EDTA-free Protease Inhibitor Cocktail Roche Life Science
Applicable Processes Inhibition, Purification
From $ 159.00 (25 Tablets)
Sizes 1 (25 Tablets)
Catalog IDs 11836170001
Added to comparison view - remove
View Product
Sodium orthovanadate, ≥90% (titration) Sigma-Aldrich
Applicable Processes /
From $ 43.13 (10 g)
Sizes 3 (10 - 250 g)
Catalog IDs S6508-10G, S6508-50G, ...
Added to comparison view - remove
View Product
Sodium orthovanadate, 99.98% trace metals basis Sigma-Aldrich
Applicable Processes /
From $ 70.02 (10 g)
Sizes 1 (10 g)
Catalog IDs 450243-10G
Added to comparison view - remove
View Product
MS-SAFE Protease and Phosphatase Inhibitor Sigma-Aldrich
Applicable Processes /
From $ 53.00 (1 Vial)
Sizes 2 (1 - 5 Vial)
Catalog IDs MSSAFE-1VL, MSSAFE-5VL
Added to comparison view - remove
View Product

Can't find what you are looking for? Request the product now and we'll find it for you (typically within 1 hour).

Request Product

Inhibitor Function

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Inhibitor Discovery

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

Inhibitor Mechanism

Inhibitors work by either obstructing an enzyme’s active site to prevent a substrate from binding with its designated enzyme or by preventing an enzyme from catalyzing its reaction. The concentration necessary to inhibit effectively (its potency), and its ability to not bind to other molecules (specificity) are how the quality of new inhibitors are judged. A new inhibitor with a high specificity and potency ensures a drug will have few side effects and low toxicity.

Inhibitor Types

Inhibitors can then be categorized into two categories: reversible or irreversible. Reversible inhibitors are those whose chemical modifications can be undone. Unsurprisingly, irreversible inhibitors covalently modify an enzyme, thus making permanent changes.

Reversible Inhibitors

When reversible inhibitors attach to enzymes, they do not undergo chemical reactions and can thus be effectively removed via dilution or dialysis. To classify reversible inhibitors, scientists look at the effects of varying their concentration.

Types of RI:

  • Competitive Inhibition: Enzyme’s target substrate and inhibitor compete for the active site.
  • Uncompetitive Inhibition: The inhibitor is only activated once the substrate binds to the enzyme.
  • Non-Competitive Inhibition: when the inhibitor merely slows the activity of the enzyme but does not restrict the substrate-enzyme complex formation.
  • Mixed Inhibition: the inhibitor and substrate can bind to the enzyme at the same time, resulting in a slowing of activity with a reduction in affinity.

Irreversible Inhibitors

Irreversible inhibition occurs when an enzyme is covalently modified. This occurs when a functional group, usually containing nitrogen mustards, aldehydes, haloalkanes, alkenes, Michael acceptors, phenyl sulfonates, or fluorophosphonates bind with the amino acid side chains present on enzymes to form covalent adducts. Such chemical reactions do not denature proteins, but rather alter their specific enzyme’s active site.