ZAGENO
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Inhibitors on ZAGENO

RNaseOFF Ribonuclease Inhibitor Applied Biological Materials
Reagent Type Inhibitors Applicable Processes cDNA synthesis, In vitro transcription, Inhibition, Real-time PCR Quantity 4000 U
From $ 80.00 (100 µl)
Sizes 1 (100 µl)
Catalog IDs G138
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cOmplete™, Mini Protease Inhibitor Cocktail Roche Life Science
Reagent Type Inhibitors Applicable Processes Inhibition, Purification Quantity 25 Tablets
From $ 154.00 (25 Tablets)
Sizes 2 (25 Tablets)
Catalog IDs 11836153001, 11836153001
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Halt™ Protease and Phosphatase Inhibitor Cocktail (100X) Thermo Scientific
Reagent Type / Applicable Processes / Quantity /
From $ 225.00 (1 ml)
Sizes 1 (1 ml)
Catalog IDs 78440
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TW-37 [10mM] SKU : 10046 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 110.00 (1 ml)
Sizes 1 (1 ml)
Catalog IDs 10046
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Caspase-8 Inhibitor (Z-LETD-FMK) [1mM] SKU : 10201 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 84.00 (100 µl)
Sizes 1 (100 µl)
Catalog IDs 10201
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AEBSF (4-(2-Aminoethyl)-benzenesulfonyl-fluoride hydrochloride) SKU : 10461 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 110.00 (500 mg)
Sizes 1 (500 mg)
Catalog IDs 10461
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E-64; (N-(N-(L-3 Trans-carboxirane-2-carbonyl)-L-leucyl)-agmatine) SKU : 10467 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 180.00 (5 mg)
Sizes 1 (5 mg)
Catalog IDs 10467
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PMSF (Phenylmethylsulfonyl fluoride) SKU : 10469 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 55.00 (5 g)
Sizes 2 (5 - 25 g)
Catalog IDs 10469, 10469-1
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Curcumin SKU : 10035 Cepham Life Sciences
Reagent Type / Applicable Processes / Quantity /
From $ 32.00 (25 mg)
Sizes 2 (25 - 50 mg)
Catalog IDs 10035-1, 10035-2
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GSK 525762A (I-BET-762) AdooQ BioScience
Reagent Type / Applicable Processes / Quantity /
From $ 306.00 (50 mg)
Sizes 1 (50 mg)
Catalog IDs A11440-50
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3-Isobutyl-1-methylxanthine Sigma-Aldrich
Reagent Type Inhibitors Applicable Processes Inhibition Quantity 100 mg
From $ 37.40 (100 mg)
Sizes 2 (100 - 250 mg)
Catalog IDs I5879-100MG, I5879-250MG
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cOmplete™ ULTRA Tablets, glass vials Protease Inhibitor Cocktail Roche Life Science
Reagent Type Inhibitors Applicable Processes Inhibition, Purification Quantity 20 Tablets, 60 Tablets
From $ 365.00 (20 Tablets)
Sizes 2 (20 - 60 Tablets)
Catalog IDs 5892988001, 6538304001
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Inhibitor Function

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Inhibitor Discovery

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

Inhibitor Mechanism

Inhibitors work by either obstructing an enzyme’s active site to prevent a substrate from binding with its designated enzyme or by preventing an enzyme from catalyzing its reaction. The concentration necessary to inhibit effectively (its potency), and its ability to not bind to other molecules (specificity) are how the quality of new inhibitors are judged. A new inhibitor with a high specificity and potency ensures a drug will have few side effects and low toxicity.

Inhibitor Types

Inhibitors can then be categorized into two categories: reversible or irreversible. Reversible inhibitors are those whose chemical modifications can be undone. Unsurprisingly, irreversible inhibitors covalently modify an enzyme, thus making permanent changes.

Reversible Inhibitors

When reversible inhibitors attach to enzymes, they do not undergo chemical reactions and can thus be effectively removed via dilution or dialysis. To classify reversible inhibitors, scientists look at the effects of varying their concentration.

Types of RI:

  • Competitive Inhibition: Enzyme’s target substrate and inhibitor compete for the active site.
  • Uncompetitive Inhibition: The inhibitor is only activated once the substrate binds to the enzyme.
  • Non-Competitive Inhibition: when the inhibitor merely slows the activity of the enzyme but does not restrict the substrate-enzyme complex formation.
  • Mixed Inhibition: the inhibitor and substrate can bind to the enzyme at the same time, resulting in a slowing of activity with a reduction in affinity.

Irreversible Inhibitors

Irreversible inhibition occurs when an enzyme is covalently modified. This occurs when a functional group, usually containing nitrogen mustards, aldehydes, haloalkanes, alkenes, Michael acceptors, phenyl sulfonates, or fluorophosphonates bind with the amino acid side chains present on enzymes to form covalent adducts. Such chemical reactions do not denature proteins, but rather alter their specific enzyme’s active site.