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Antibiotics
BIOMYC-3 SKU: PK-CC03-038-1
CAS Number
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Molecular Formula
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/
Concentration
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/
Scientific Score
5.86
Brand
PromoCell
Sizes
3 (10 - 100 ml)
Available From
1 Vendor
Price Range
$ 50.63 - $ 235.13
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Antibiotics
InSolution™ Rapamycin - Calbiochem
Scientific Score
7.44
Brand
MilliporeSigma
Sizes
2 (1 - 500 mg)
Available From
3 Vendors
Price Range
$ 147.00 - $ 226.44
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Antibiotics
Corning™ cellgro™ Kanamycin Sulfate, Powder
CAS Number
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Molecular Formula
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Concentration
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Scientific Score
6.31
Brand
Corning
Sizes
1 (5 g)
Available From
1 Vendor
Price
$ 102.47
Catalog IDs
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Antibiotics
Boston Biochem™ Geldanamycin (HSP90 inhibitor), Boston BioChem™
CAS Number
/
/
Molecular Formula
C29H40N2O9
C29H40N2O9
Concentration
/
/
Scientific Score
5.02
Brand
Boston Biochem
Sizes
1 (100 µg)
Available From
1 Vendor
Price
$ 115.00
Catalog IDs
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Antibiotics
Corning™ Extracellular Matrix, Human
CAS Number
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Molecular Formula
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Concentration
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/
Scientific Score
6.65
Brand
Corning
Sizes
1 (1 mg)
Available From
1 Vendor
Price
$ 246.82
Catalog IDs
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Antibiotics
Corning™ Linoleic Acid/Albumin Complex
CAS Number
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/
Molecular Formula
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Concentration
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Scientific Score
7.07
Brand
Corning
Sizes
1 (500 mg)
Available From
1 Vendor
Price
$ 121.60
Catalog IDs
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Antibiotics
Penicillin-Streptomycin Mixture 20000 U
CAS Number
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Molecular Formula
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Concentration
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Scientific Score
6.28
Brand
Lonza
Sizes
1 (500 ml)
Available From
2 Vendors
Price Range
$ 54.28 - $ 74.30
Catalog IDs
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Antibiotics
Antibiotic K252A (Antibiotic SF 2370) SKU: K0000-50C
CAS Number
99570-78-2
99570-78-2
Molecular Formula
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/
Concentration
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Scientific Score
5.67
Brand
US Biological
Sizes
1 (500 µg)
Available From
1 Vendor
Price
$ 426.00
Catalog IDs
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Antibiotics
Antibiotic TPU-0037-A (30-Demethyl-lydicamycin) SKU: A2297-38M
CAS Number
485815-59-6
485815-59-6
Molecular Formula
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/
Concentration
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/
Scientific Score
5.02
Brand
US Biological
Sizes
1 (500 µg)
Available From
1 Vendor
Price
$ 582.00
Catalog IDs
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Antibiotics
15mg/mL Tetracycline in 50% ethanol Solution
CAS Number
/
/
Molecular Formula
C22H24N2O8
C22H24N2O8
Concentration
/
/
Scientific Score
7.75
Brand
Teknova
Sizes
1 (25 ml)
Available From
1 Vendor
Price
$ 22.27
Catalog IDs
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Antibiotics
Streptomycin Sulfate SKU: SB0494
Scientific Score
2.57
Brand
Bio Basic
Sizes
2 (50 - 250 g)
Available From
1 Vendor
Price Range
$ 20.58 - $ 60.44
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Antibiotics
Kanamycin
CAS Number
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Molecular Formula
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Concentration
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Scientific Score
7.11
Brand
TransGen Biotech
Sizes
1 (1 ml)
Available From
1 Vendor
Price
$ 4.62
Catalog IDs
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Antibiotic Functions

Antibiotics (or antibacterials) are substances that are capable of either killing bacteria or inhibiting bacterial growth but are not effective against viruses. They are widely used as drugs to treat diseases caused by bacterial infections like tuberculosis, meningitis or salmonella infections. Antibiotics are grouped into families, with Penicillins being one of the first discovered antibiotics.

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Mechanisms

The antibacterial effect is mediated through different mechanisms:

• Binding to the bacterial 30S ribosomal subunit with subsequential inhibition of protein synthesis (e.g. Aminoglycosides)

• Inhibition of the synthesis of the peptidoglycan layer in bacterial cell walls (e.g. Penicillins)

• Inhibition of protein synthesis by preventing the initiation step of translation (e.g. Oxazolidinones)

• Preventing DNA replication and transcription by inhibition of the DNA gyrase or the topoisomerase IV (e.g. Quinolones)

• Folate synthesis inhibition resulting in the disability to synthesize nucleic acids (e.g. Sulfonamides)

Antibiotics are very effective to handle bacterial diseases and are readily available. This results in an overuse and an increasing resistance of bacteria against antibiotics. Especially in the animal husbandry antibiotics are routinely used.

Applications

In research, antibiotics are of high importance for various techniques.

Cloning

In molecular cloning procedures, they are used to distinguish between bacteria that have incorporated exogenous DNA through transformation and bacteria where transformation has failed. The selection is achieved by introducing an antibiotic resistance into the bacteria together with the genetic modification. Only successfully transformed cells are able to survive on the antibiotic supplemented agar plates.

Protein Synthesis/Gene Expression

For the synthesis of recombinant proteins or conditional gene expression, systems that alter the expression of specific genes depending on the presence or absence of an antibiotic are available. One example of such a system is the Tet-On system which switches on gene expression in the presence of tetracycline or the more stable derivate doxycycline. These systems may also be used in generating transgenic mice with a conditionally expressed gene of interest.

Culture

In cell culture, you may use a mix of penicillin and streptomycin (Pen-Strep) to decrease the risk of bacterial infection of your cell lines. Many cell lines are contaminated with Mycoplasma, a genus of bacteria which lack a cell wall. When detected, you can treat a Mycoplasma infection with several antibiotic-containing antimycoplasma reagents.