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Growth Factors

Human Insulin-like Growth Factor II (hIGF-II)

Cell Signaling Technology

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From
$ 65.00 (10 µg)
Sizes
1 (10 µg)
Catalog IDs
25690S
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Growth Factors

Purmorphamine SKU : SML0868

Sigma-Aldrich

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From
$ 112.00 (5 mg)
Sizes
2 (5 - 25 mg)
Catalog IDs
SML0868-5MG, SML0868-25MG
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Growth Factors

RU-SKI 43 maleate SKU : SML1000

Sigma-Aldrich

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From
$ 180.00 (5 mg)
Sizes
2 (5 - 25 mg)
Catalog IDs
SML1000-5MG, SML1000-25MG
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Growth Factors

K02288 SKU : SML1307

Sigma-Aldrich

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From
$ 120.00 (5 mg)
Sizes
2 (5 - 25 mg)
Catalog IDs
SML1307-5MG, SML1307-25MG
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Growth Factors

A20 human SKU : SRP0444

Sigma-Aldrich

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From
$ 497.00 (50 µg)
Sizes
1 (50 µg)
Catalog IDs
SRP0444-50UG
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Growth Factors

Activin A human SKU : SRP3003

Sigma-Aldrich

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From
$ 264.50 (10 µg)
Sizes
1 (10 µg)
Catalog IDs
SRP3003-10UG
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Growth Factors

Angiopoietin-1 human SKU : SRP3007

Sigma-Aldrich

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From
$ 264.50 (5 µg)
Sizes
1 (5 µg)
Catalog IDs
SRP3007-5UG
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Growth Factors

Beta NGF human SKU : SRP3015

Sigma-Aldrich

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From
$ 264.50 (20 µg)
Sizes
1 (20 µg)
Catalog IDs
SRP3015-20UG
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Growth Factors

ENA-78 (8-78) human SKU : SRP3030

Sigma-Aldrich

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From
$ 264.50 (20 µg)
Sizes
1 (20 µg)
Catalog IDs
SRP3030-20UG
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Growth Factors

FGF-16 human SKU : SRP3038

Sigma-Aldrich

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From
$ 264.50 (25 µg)
Sizes
1 (25 µg)
Catalog IDs
SRP3038-25UG
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Growth Factors

FGF-23 human SKU : SRP3039

Sigma-Aldrich

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From
$ 264.50 (20 µg)
Sizes
1 (20 µg)
Catalog IDs
SRP3039-20UG
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Growth Factors

HCC-1 (CCL14) (72 aa) human SKU : SRP3054

Sigma-Aldrich

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Purity
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From
$ 264.50 (10 µg)
Sizes
1 (10 µg)
Catalog IDs
SRP3054-10UG
Added to comparison remove item

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Growth Factor Function

Growth factors act as signaling molecules between cells. The signaling may occur between local cells (paracrine signaling), between distant cells (endocrine signaling) or the same cell that produced the signal binds its “own” growth factor (autocrine signaling). To induce the signal cascade, growth factors bind to their specific receptor situated on the cell membrane or, in the case of the fat-soluble steroid hormones, inside of the cell. Growth factors often target receptors of the tyrosine kinase family followed by downstream signaling transduction pathways like the MAP kinase signaling cascade.

Problems in the lab? Find the solutions in our Knowledge and Troubleshooting sections. Alternatively, our Community of experienced researchers can help! Still confused? See How ZAGENO Works.

Growth Factor Stimulation

Growth factors are important for the regulation of many different cellular processes. Usually, they are naturally occurring proteins or steroid hormones and are capable of stimulating:

• cell growth

• proliferation

• tissue repair

• cellular differentiation

• cell survival

• inflammation

There are many different growth factors which are often grouped into families like the Transforming Growth Factor (TGF) family or the family of Interleukins (IL).

Applications In Vivo and In Vitro

In vivo, many cells require the presence of different growth factors to proliferate or differentiate and to maintain their viability. In in vitro cell cultures, some cell lines require the addition of growth factors to the culture medium in order to proliferate. Additionally, they could be used to stimulate differentiation of cell lines.

In the clinic, growth factors may be utilized in the treatment of different diseases. For example, neutropenia may be treated with hematopoietic growth factors (granulocyte-colony stimulating factor (G-CSF)).

Available growth factors are often produced by genetic engineering. Therefore, recombinant bacteria, which have the particular genes inserted and are able to transcribe these genes as well as to translate the mRNA into the corresponding proteins, are produced. After protein extraction and purification, the growth factors are ready to be used in your experiments.