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Channel Blockers

Score 4.88

Lomerizine dihydrochloride SKU : L6295

Sigma-Aldrich

Molecular Formula
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/
Molecular Weight
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/
CAS Number
/
/
From
$ 75.50 (10 mg)
Sizes
2 (10 - 50 mg)
Catalog IDs
L6295-10MG, L6295-50MG
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Channel Blockers

Score 3.72

R(+)-IAA-94 SKU : I117

Sigma-Aldrich

Molecular Formula
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/
Molecular Weight
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/
CAS Number
/
/
From
$ 147.00 (10 mg)
Sizes
3 (10 - 250 mg)
Catalog IDs
I117-10MG-I, I117-50MG-I, ...
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Channel Blockers

Score 6.63

E-4031 . dihydrochloride

Enzo Life Sciences

Molecular Formula
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/
Molecular Weight
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/
CAS Number
/
/
From
$ 170.00 (5 mg)
Sizes
2 (5 - 25 mg)
Catalog IDs
BML-KC158-0005, BML-KC158-0025
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Channel Blockers

Score 6.10

Amiloride . hydrochloride . dihydrate

Enzo Life Sciences

Molecular Formula
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/
Molecular Weight
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/
CAS Number
/
/
From
$ 40.00 (1 g)
Sizes
1 (1 g)
Catalog IDs
ALX-550-212-G001
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Channel Blockers

Score 6.40

(±)-Verapamil . hydrochloride

Enzo Life Sciences

Molecular Formula
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/
Molecular Weight
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/
CAS Number
/
/
From
$ 34.00 (1 g)
Sizes
2 (1 - 5 g)
Catalog IDs
ALX-550-306-G001, ALX-550-306-G005
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Channel Blockers

Score 6.13

Bumetanide

Enzo Life Sciences

Molecular Formula
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Molecular Weight
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CAS Number
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/
From
$ 199.00 (5 g)
Sizes
1 (5 g)
Catalog IDs
BML-EI168-0005
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Channel Blockers

Score 4.47

Tetrodotoxin citrate

Tocris

Molecular Formula
C11H17N3O8
C11H17N3O8
Molecular Weight
319.27
319.27
CAS Number
/
/
From
$ 219.00 (1 mg)
Sizes
1 (1 mg)
Catalog IDs
1069/1
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Channel Blockers

Score 3.08

Kynurenic acid sodium salt SKU: HB0363

Hello Bio

From
$ 21.00 (100 mM)
Sizes
3 (1 - 100 g)
Catalog IDs
HB0363-1G, HB0363-5G, ...
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Channel Blockers

Score 3.39

CNQX disodium salt SKU: HB0205

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From
$ 36.00 (1 mg)
Sizes
5 (1 - 50 mg)
Catalog IDs
HB0205-1MG, HB0205-10MG, ...
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Channel Blockers

Score 3.42

D-AP5 SKU: HB0225

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From
$ 37.00 (1 mg)
Sizes
6 (1 - 100 mg)
Catalog IDs
HB0225-1MG, HB0225-10MG, ...
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Channel Blockers

Score 0.69

GYKI 52466 SKU: HB0311

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From
$ 107.00 (10 mg)
Sizes
1 (10 mg)
Catalog IDs
HB0311-10MG
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Channel Blockers

Score 2.06

Ibotenic acid SKU: HB0330

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From
$ 57.00 (1 mg)
Sizes
2 (1 - 5 mg)
Catalog IDs
HB0330-1MG, HB0330-5MG
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Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

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Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection