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Channel Blockers
Amiodarone Hydrochloride SKU: SIH-393
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C25H29I2NO3•HCl
C25H29I2NO3•HCl
Scientific Score
3.73
Brand
StressMarq Biosciences
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 69.00
Catalog IDs
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Channel Blockers
Felodipine SKU: SIH-323
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C18H19Cl2NO4
C18H19Cl2NO4
Scientific Score
3.87
Brand
StressMarq Biosciences
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 59.00 - $ 205.00
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Channel Blockers
Nifedipine SKU: SIH-309
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C17H18N2O6
C17H18N2O6
Scientific Score
3.87
Brand
StressMarq Biosciences
Sizes
2 (1 - 5 g)
Available From
1 Vendor
Price Range
$ 41.00 - $ 129.00
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Channel Blockers
L-Aspartic acid
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C4H7NO4
C4H7NO4
Scientific Score
8.45
Brand
Tocris
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 59.00
Catalog IDs
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Channel Blockers
Taurine
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C2H7NO3S
C2H7NO3S
Scientific Score
8.32
Brand
Tocris
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 59.00
Catalog IDs
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Channel Blockers
(-)-Nicotine ditartrate
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C10H14N2·2C4H6O6
C10H14N2·2C4H6O6
Scientific Score
8.41
Brand
Tocris
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 69.00
Catalog IDs
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Channel Blockers
1-Phenylbiguanide hydrochloride
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C8H11N5·HCl
C8H11N5·HCl
Scientific Score
8.29
Brand
Tocris
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 69.00
Catalog IDs
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Channel Blockers
Glibenclamide
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C23H28ClN3O5S
C23H28ClN3O5S
Scientific Score
8.77
Brand
Tocris
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 69.00
Catalog IDs
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Channel Blockers
(-)-Cotinine
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C10H12N2O
C10H12N2O
Scientific Score
8.61
Brand
Tocris
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 79.00
Catalog IDs
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Channel Blockers
4-Aminopyridine
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C5H6N2
C5H6N2
Scientific Score
7.66
Brand
Tocris
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 79.00
Catalog IDs
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Channel Blockers
9-AC
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C15H10O2
C15H10O2
Scientific Score
8.32
Brand
Tocris
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 79.00
Catalog IDs
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Channel Blockers
Dantrolene, sodium salt
Chemical Name
/
/
Concentration
/
/
Molecular Formula
C14H9N4NaO5
C14H9N4NaO5
Scientific Score
8.65
Brand
Tocris
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 79.00
Catalog IDs
Added to comparison remove item

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Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

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Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection