Customer Service +1 617 855 5944 +1 617 855 5944
True-Stain Monocyte Blocker™
Scientific Score
2.83
Brand
BioLegend
Sizes
3 (25 - 500 Reactions)
Available From
1 Supplier
Price Range
$ 40.00 - $ 480.00
Added to comparison remove item
Loperamide hydrochloride SKU : L4762
Chemical Name
/
Concentration
/
Molecular Formula
C29H34Cl2N2O2
C29H34Cl2N2O2
Scientific Score
9.13
Brand
Sigma-Aldrich
Sizes
2 (5 - 25 g)
Available From
2 Suppliers
Price Range
$ 120.00 - $ 527.13
Added to comparison remove item
Lomerizine dihydrochloride SKU : L6295
Chemical Name
/
Concentration
/
Molecular Formula
C27H32Cl2F2N2O3
C27H32Cl2F2N2O3
Scientific Score
4.88
Brand
Sigma-Aldrich
Sizes
2 (10000 - 50000 µg)
Available From
2 Suppliers
Price Range
$ 79.30 - $ 320.93
Added to comparison remove item
R(+)-IAA-94 SKU : I117
Chemical Name
/
Concentration
/
Molecular Formula
/
Scientific Score
3.72
Brand
Sigma-Aldrich
Sizes
3 (10000 - 250000 µg)
Available From
1 Supplier
Price Range
$ 168.68 - $ 2,241.71
Added to comparison remove item
ω-Agatoxin IVA
Chemical Name
/
Concentration
/
Molecular Formula
C217H360N68O60S10
C217H360N68O60S10
Scientific Score
3.54
Brand
Alomone Labs
Sizes
6 (50 - 5000 µg)
Available From
1 Supplier
Price Range
$ 127.00 - $ 1,973.00
Added to comparison remove item
QX 314 chloride
Chemical Name
/
Concentration
/
Molecular Formula
C16H27ClN2O
C16H27ClN2O
Scientific Score
9.29
Brand
Tocris
Sizes
1 (50000 µg)
Available From
1 Supplier
Price
$ 129.00
Catalog IDs
Added to comparison remove item
LOE 908 hydrochloride
Chemical Name
/
Concentration
/
Molecular Formula
C41H49ClN2O9
C41H49ClN2O9
Scientific Score
8.51
Brand
Tocris
Sizes
2 (10000 - 50000 µg)
Available From
1 Supplier
Price Range
$ 169.00 - $ 705.00
Added to comparison remove item
Glimepiride
Chemical Name
/
Concentration
/
Molecular Formula
C24H34N4O5S
C24H34N4O5S
Scientific Score
9.44
Brand
Tocris
Sizes
2 (10000 - 50000 µg)
Available From
1 Supplier
Price Range
$ 59.00 - $ 199.00
Added to comparison remove item
Ambroxol hydrochloride
Chemical Name
/
Concentration
/
Molecular Formula
C13H19Br2ClN2O
C13H19Br2ClN2O
Scientific Score
9.53
Brand
Tocris
Sizes
1 (50000 µg)
Available From
1 Supplier
Price
$ 95.00
Catalog IDs
Added to comparison remove item
Talniflumate
Chemical Name
/
Concentration
/
Molecular Formula
C21H13F3N2O4
C21H13F3N2O4
Scientific Score
9.44
Brand
Tocris
Sizes
2 (10000 - 50000 µg)
Available From
1 Supplier
Price Range
$ 99.00 - $ 419.00
Added to comparison remove item
TFB-TBOA
Chemical Name
/
Concentration
/
Molecular Formula
C19H17F3N2O6
C19H17F3N2O6
Scientific Score
9.26
Brand
Tocris
Sizes
2 (1000 - 10000 µg)
Available From
1 Supplier
Price Range
$ 139.00 - $ 295.00
Added to comparison remove item
Amlodipine besylate
Chemical Name
/
Concentration
/
Molecular Formula
C26H31ClN2O8S
C26H31ClN2O8S
Scientific Score
7.03
Brand
Tocris
Sizes
1 (50000 µg)
Available From
1 Supplier
Price
$ 99.00
Catalog IDs
Added to comparison remove item

Can't find what you are looking for? Request the product now and we'll find it for you (typically within 1 hour).

Request Product

Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

One Marketplace. All of Biotech.
Your Perfect Solution - Millions of Products - Expert Advice

Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection