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Amlodipine Besylate
Chemical Name
/
Concentration
/
Molecular Formula
C26H31ClN2O8S
C26H31ClN2O8S
Brand
US Biological
Sizes
5 (1 - 500 g)
Available From
1 Vendor
Price Range
$ 184.00 - $ 775.00
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HC 030031 SKU: HB1158
Chemical Name
/
Concentration
/
Molecular Formula
C18H21N5O3
C18H21N5O3
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 73.00 - $ 287.00
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AMTB hydrochloride SKU: HB1167
Chemical Name
/
Concentration
/
Molecular Formula
C23H27ClN2O2S
C23H27ClN2O2S
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (5 - 25 mg)
Available From
1 Vendor
Price Range
$ 67.00 - $ 264.00
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Amlodipine besylate SKU: HB1214
Chemical Name
/
Concentration
/
Molecular Formula
C26H31ClN2O8S
C26H31ClN2O8S
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 75.00
Catalog IDs
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Felodipine SKU: HB1222
Chemical Name
/
Concentration
/
Molecular Formula
C18H19Cl2NO4
C18H19Cl2NO4
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (50 - 100 mg)
Available From
1 Vendor
Price Range
$ 499.00 - $ 748.00
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Isradipine SKU: HB1223
Chemical Name
/
Concentration
/
Molecular Formula
C19H21N3O5
C19H21N3O5
Scientific Score
2.83
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 60.00 - $ 276.00
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Nifedipine SKU: HB1228
Chemical Name
/
Concentration
/
Molecular Formula
C17H18N2O6
C17H18N2O6
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 59.00
Catalog IDs
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4-Aminopyridine SKU: HB1073
Chemical Name
/
Concentration
/
Molecular Formula
C5H6N2
C5H6N2
Scientific Score
1.46
Brand
Hello Bio
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 40.00
Catalog IDs
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Zatebradine hydrochloride SKU: HB1151
Chemical Name
/
Concentration
/
Molecular Formula
C26H37ClN2O5
C26H37ClN2O5
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 457.00
Catalog IDs
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Zonisamide SKU: HB0675
Chemical Name
/
Concentration
/
Molecular Formula
C8H8N2O3S
C8H8N2O3S
Scientific Score
2.83
Brand
Hello Bio
Sizes
3 (10 - 100 mg)
Available From
1 Vendor
Price Range
$ 104.00 - $ 628.00
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BAPTA-AM SKU: HB0981
Chemical Name
/
Concentration
/
Molecular Formula
C34H40N2O18
C34H40N2O18
Scientific Score
0.69
Brand
Hello Bio
Sizes
1 (25 mg)
Available From
1 Vendor
Price
$ 99.00
Catalog IDs
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Co 102862 SKU: HB1013
Chemical Name
/
Concentration
/
Molecular Formula
C14H12FN3O2
C14H12FN3O2
Scientific Score
2.06
Brand
Hello Bio
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 102.00 - $ 409.00
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Channel Blocker Function

Channel blockers are signal transduction reagents able to prevent the opening of an ion channel, acting as antagonists. Different type of molecules, such as cations, anions, amino acids, peptides and other chemicals can block channels.

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Ion Channels

Ion channels are protein complexes, often comprised out of many proteins, that form pores inside a membrane. These channels can selectively permit the passage of ions through the membrane in which they are situated. Often channels can switch between an open and a closed state by different stimuli. Since ions carry electrical charges, ion channels are important for the regulation of the membrane potential, which is necessary for processes such as neurotransmission, muscle contraction and T-cell activation. Whether the particular ions can pass through the channel or not depends on different factors like:

• Ion concentration inside or outside of the membrane

• Condition of the channel (open / closed)

• Presence of agonists or antagonists

Channel Blocker Mechanisms and Applications

Channel blockers can act specifically on one channel, or on a range of different channels. The blockage is mediated by the binding of the channel blocker to a portion of the channel. The different mechanisms vary between channels and blockers, but all blockers produce an alteration in the electrochemical gradient of the cell membrane.

Prominent examples of channel blockers are calcium (Ca) channel blockers, which are used as antihypertensive drugs or various toxins like Tetrodotoxin (TTX) that act through the blockage of ion channels. Other blockers are specific to potassium (K) and sodium (Na) channels.

Channel blockers are used for various experiments like:

• Evaluation of signal transduction pathways

• Production or suppression of physiological responses

• Treatment of diseases

• Ion channel detection