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Deferasirox Salicyloyl Ester SKU: 163619
Chemical Name
/
CAS Number
1395346-28-7
1395346-28-7
Purity
/
Brand
US Biological
Sizes
1 (10 mg)
Available From
1 Vendor
Price
$ 432.00
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5-Methoxycarbonyl Deferasirox SKU: 161936
Chemical Name
/
CAS Number
1395346-29-8
1395346-29-8
Purity
/
Brand
US Biological
Sizes
1 (2.5 mg)
Available From
1 Vendor
Price
$ 496.00
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4-Amino-D,L-benzylsuccinic Acid SKU: A1375-66
Chemical Name
/
CAS Number
/
Purity
/
Brand
US Biological
Sizes
1 (100 mg)
Available From
1 Vendor
Price
$ 389.00
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(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid SKU: C7936-01
Chemical Name
/
CAS Number
61696-54-66
61696-54-66
Purity
/
Brand
US Biological
Sizes
1 (25 mg)
Available From
1 Vendor
Price
$ 368.00
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Brand
US Biological
Sizes
1 (50 mg)
Available From
1 Vendor
Price
$ 347.00
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N-[tert-Butyloxycarbonyl]-6-hydroxy-DL-norleucine SKU: 165270
Chemical Name
/
CAS Number
81505-64-8
81505-64-8
Purity
/
Brand
US Biological
Sizes
1 (10 mg)
Available From
1 Vendor
Price
$ 389.00
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Zinpyr-4 SKU: 022967
Chemical Name
/
CAS Number
502467-23-4
502467-23-4
Purity
/
Brand
US Biological
Sizes
1 (1 mg)
Available From
1 Vendor
Price
$ 389.00
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Dithizone SKU: 010879
Chemical Name
/
CAS Number
60-10-6
60-10-6
Purity
/
Brand
US Biological
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 333.00
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1,10-Phenanthroline SKU: 019357
Chemical Name
/
CAS Number
66-71-7
66-71-7
Purity
/
Brand
US Biological
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 347.00
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Nitrilotriacetic Acid SKU: 165627
Chemical Name
/
CAS Number
139-13-9
139-13-9
Purity
/
Brand
US Biological
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 312.00
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BAPTA-tetracesium Salt SKU: 003162
Chemical Name
/
CAS Number
480436-84-8
480436-84-8
Purity
/
Brand
US Biological
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 389.00
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BAPTA-Tetramethyl Ester SKU: B0078
Chemical Name
/
CAS Number
125367-34-2
125367-34-2
Purity
/
Brand
US Biological
Sizes
1 (1 g)
Available From
1 Vendor
Price
$ 375.00
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Chelator Function and Structure

Chelators or chelating agents are small water-soluble molecules which form complexes with metal ions and are occasionally fluorescent. As a complex (chelate) they are inert in solution; requiring high energy for dissociation. However, metal exchange is possible in labile complexes. Sequestering agents represent chelators which produce soluble metal complexes.

The functional groups of chelators are two of =O, -NH2 or -COO-. These are groups which donate an electron pair to the metal ion to form the complex and must be positioned correctly to allow ring formation. Chelators represent a major component of cellular metabolism.

Popular chelators include EDTA and Deferoxamine Mesylate.

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Chelator Classifications

Natural Chelators (can aid in physiological systems transport iron and oxygen) include:

• Phosphates

• Ferrioxamines

• Phenolics

• Ionophores (monensin, valinomycin, gramicidin)

• Tetrapyrrols

Synthetic Chelators (suitable for separating metals in solutions) include:

• ionophores Nitrilotriacetic acid, NTA ortho-Phenanthroline

• 2,2'-Bipyridyl

• Salicylic acid

• Dimercaptopropanol

• Triethanolamine, TEA

• Ethylene glycol-bis-(2-aminoethyl)-N,N,N', N'-tetraacetic acid (EGTA)

• Ethylenediaminotetraacetic acid, EDTA Ethylenedioxy-diethylene-dinitrilo-tetraacetic acid

Chelator Applications

• Animal food addition to prevent precipitation or absorption of essential metals

• Elution in chelation affinity chromatography (EDTA or EGTA)

• Reduce metal interference when using metal indicators for measuring intracellular cation concentration (Ca2+ in FURA or QUIN).

• Reagent in quantitative complexometric determination of metals

• Removal of complex inhibitory heavy metals from buffer solutions

• Nutrient solution component for microorganisms/plants in hydroculture

Calcium Chelators

Calcium chelators have a high affinity for calcium ions through carboxylic groups. Binding can be affected by pH, other ions, and coordination to other proteins.

Calcium buffers are produced with the help of BAPTA. The chelator can also be used study calcium cell signaling by controlling cytosolic calcium concentration.

General calcium chelator use:

• Controlling Ca2+ levels intracellularly and extracellularly

• NMR analysis of Ca2+

• Research into calcium shuttling, mobilization and spatial calcium buffering