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Detergents & Surfactants

Score 9.58

N-Lauroylsarcosine sodium salt SKU : 61745

Sigma-Aldrich

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From
$ 28.00 (50 g)
Sizes
3 (1 - 250 kg)
Catalog IDs
61745-1KG, 61745-50G, ...
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Detergents & Surfactants

Score 9.53

Sodium glycodeoxycholate SKU : g9910

Sigma-Aldrich

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$ 42.75 (250 mg)
Sizes
3 (1 - 250 g)
Catalog IDs
G9910-1G, G9910-5G, ...
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Detergents & Surfactants

Score 9.12

Benzalkonium chloride SKU : b6295

Sigma-Aldrich

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From
$ 72.00 (100 g)
Sizes
2 (100 - 500 g)
Catalog IDs
B6295-100G, B6295-500G
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Detergents & Surfactants

Score 6.85

C7BzO SKU : c0856

Sigma-Aldrich

From
$ 115.00 (1 g)
Sizes
1 (1 g)
Catalog IDs
C0856-1G
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Detergents & Surfactants

Score 9.20

CHAPSO SKU : c3649

Sigma-Aldrich

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From
$ 87.00 (500 mg)
Sizes
4 (1 - 500 g)
Catalog IDs
C3649-1G, C3649-5G, ...
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Detergents & Surfactants

Score 9.68

CHAPSO SKU : c4695

Sigma-Aldrich

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From
$ 153.00 (500 mg)
Sizes
3 (1 - 500 g)
Catalog IDs
C4695-1G, C4695-5G, ...
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Detergents & Surfactants

Score 9.79

TWEEN® 80 SKU : P8074

Sigma-Aldrich

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From
$ 27.76 (100 ml)
Sizes
2 (100 - 500 ml)
Catalog IDs
P8074-100ML, P8074-500ML
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Detergents & Surfactants

Score 9.00

Dihexadecyl phosphate SKU : d2631

Sigma-Aldrich

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From
$ 71.50 (1 g)
Sizes
4 (1 - 25 g)
Catalog IDs
D2631-1G, D2631-5G, ...
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Detergents & Surfactants

Score 7.10

Lithium 3,5-diiodosalicylate SKU : d3635

Sigma-Aldrich

From
$ 25.75 (1 g)
Sizes
3 (1 - 25 g)
Catalog IDs
D3635-1G, D3635-5G, ...
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Detergents & Surfactants

Score 9.91

Sodium deoxycholate monohydrate SKU : d5670

Sigma-Aldrich

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From
$ 182.00 (5 g)
Sizes
2 (5 - 25 g)
Catalog IDs
D5670-5G, D5670-25G
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Detergents & Surfactants

Score 7.10

Decyl β-D-maltopyranoside SKU : d7658

Sigma-Aldrich

From
$ 125.00 (500 mg)
Sizes
3 (1 - 500 g)
Catalog IDs
D7658-1G, D7658-5G, ...
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Detergents & Surfactants

Score 9.06

Dodecyltrimethylammonium bromide SKU : d8638

Sigma-Aldrich

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From
$ 98.00 (25 g)
Sizes
2 (25 - 100 g)
Catalog IDs
D8638-25G, D8638-100G
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Detergent Function & Application

Detergents effectively solubilize hydrophobic molecules; they are small amphipathic molecules consisting of a long alkyl chain (hydrophobic) tail attached to hydrophilic/ water solubility enhancing functional groups (a polar head). Examples include sodium dodecyl sulfate, CHAPS, and polyethylene glycol.

Applications of detergents include liposome preparation, cell lysis, analyte precipitation in solutions, solubilization of proteins and lipids, DNA & RNA extraction, as well as preventing non-specific binding in immunoassays and westerns.

The detergent type depends on the charge of the head group, whether it is ionic, non-ionic or zwitterionic.

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Anionic Detergents

Anionic Detergents have a negative charge and are used in DNA or RNA purification, due to their ability to disrupt cell membranes and denature proteins. However, these detergents are sensitive to ionic strength, pH and counterion nature. They may also interfere with charge-based analytical methods. Examples include:

• Sodium cholate

• Sodium deoxycholate

• Sodium glycocholate

• Sodium taurocholate

• Sodium Taurodeoxycholate

• N-lauryl sarcosine (Sarkosyl solution)

• Lithium dodecyl sulfate (LDS)

• Sodium dodecyl sulfate (SDS) (a vital component of SDS-PAGE)

Cationic Detergents

Cationic Detergents have a positive charge and are therefore useful at residual anionic detergents. They can be used as surfactants in drug or vaccine delivery, while also applying to DNA extraction. Due to being characteristically germicidal, they may also be used as disinfectants. Examples include CTAB (hexadecyltrimethylammonium bromide) and TTAB (Trimethyltetradecyl ammonium bromide).

Non-ionic Detergents

Non-ionic detergents are milder and therefore less likely to denature proteins, however shorter hydrophobic chain lengths may cause some denaturation.

• Poly (oxyethylene) ethers (& related polymers) have hydrophobic tails and a neutral, polar head group. Popular oxyethylene polymers are Tween 20 and Tween 80

• Bile Salts have a steroid core with a polar or apolar structure; they are less denaturing than similar detergents

• Glycosidic Detergents have a carbohydrate (glucose/maltose) polar head group and a nonpolar tail of between 7-14 carbons.

Zwitterionic Detergents

Zwitterionic detergents have a neutral charge and are therefore also less denaturing; critical applications are disrupting protein-protein bonds and reducing aggregation. These assets are put to good use in mass spectrometry, chromatography, electrophoresis and solubilization of cellular organelles and inclusion bodies.