Customer Service +1 617 855 5944 +1 617 855 5944
Cidofovir, [5-3H] ≥97% (by HPLC) MORpure™
Inhibitor Type
/
Purity
/
CAS Number
339532-39-7
339532-39-7
Brand
Moravek
Sizes
3 (50 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,169.05 - $ 4,936.54
Added to comparison remove item
Brand
Moravek
Sizes
2 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,118.08 - $ 2,818.08
Added to comparison remove item
Brand
Moravek
Sizes
3 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,131.15 - $ 1,982.75
Added to comparison remove item
Valproic acid, sodium salt, [3H] ≥97% (by HPLC) MORpure™
Inhibitor Type
/
Purity
/
CAS Number
2086336-95-8
2086336-95-8
Brand
Moravek
Sizes
2 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 741.60 - $ 1,024.85
Added to comparison remove item
D-Ribavirin, [triazole-5-3H] ≥97% (by HPLC) MORpure™
Inhibitor Type
/
Purity
/
CAS Number
2086327-92-4
2086327-92-4
Brand
Moravek
Sizes
2 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,024.85 - $ 1,611.95
Added to comparison remove item
Ochratoxin A, [3H] ≥96% (by HPLC)
Inhibitor Type
/
Purity
/
CAS Number
189152-21-4
189152-21-4
Brand
Moravek
Sizes
3 (50 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 849.75 - $ 3,458.85
Added to comparison remove item
Nicotinamide, [6-3H(N)] ≥95% (by HPLC)
Inhibitor Type
/
Purity
/
CAS Number
2086336-93-6
2086336-93-6
Brand
Moravek
Sizes
2 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,471.15 - $ 3,687.69
Added to comparison remove item
Docetaxel
Inhibitor Type
/
Purity
/
CAS Number
114977-28-5
114977-28-5
Brand
Moravek
Sizes
3 (50 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,174.20 - $ 4,165.00
Added to comparison remove item
Clevudine, [5'-3H] ≥97% (by HPLC) MORpure™
Inhibitor Type
/
Purity
/
CAS Number
2086328-20-1
2086328-20-1
Brand
Moravek
Sizes
2 (250 - 1000 µCi)
Available From
1 Vendor
Price Range
$ 1,570.75 - $ 4,315.70
Added to comparison remove item
MLN9708
Inhibitor Type
/
Purity
/
CAS Number
/
Brand
Selleck Chemicals
Sizes
3 (5 - 50 mg)
Available From
1 Vendor
Price Range
$ 222.31 - $ 970.00
Added to comparison remove item
Raltegravir
Inhibitor Type
/
Purity
/
CAS Number
/
Brand
Selleck Chemicals
Sizes
4 (1 - 50 ml)
Available From
1 Vendor
Price Range
$ 120.00 - $ 876.15
Added to comparison remove item
Trametinib
Inhibitor Type
/
Purity
/
CAS Number
/
Brand
Selleck Chemicals
Sizes
2 (10 - 50 mg)
Available From
1 Vendor
Price Range
$ 210.00 - $ 670.00
Added to comparison remove item

Can't find what you are looking for? Request the product now and we'll find it for you (typically within 1 hour).

Request Product

Inhibitor Function

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

One Marketplace. All of Biotech.
Your Perfect Solution - Millions of Products - Expert Advice

Inhibitor Discovery

As its name implies, inhibitors simply slow the activity of its target enzyme. Although inhibitors may seem counterintuitive to use for medical treatment, as most enzymatic activity is required for biological processes, inhibitors are quite effective at stopping pathogens or correcting imbalances. This is not to say inhibitors are solely synthetic. Organisms use inhibitors to protect themselves from potentially damaging proteins like nucleases or to regulate their metabolism. Such negative feedback slows overproduction of certain molecules and maintains the homeostasis of a cell. So, many drugs are enzymatic and are a key area in drug discovery within biochemistry and pharmacology. Inhibitors are used in a range of treatment, including chemotherapy, antibiotics, metabolic control, pesticides, and poisons.

Inhibitor Mechanism

Inhibitors work by either obstructing an enzyme’s active site to prevent a substrate from binding with its designated enzyme or by preventing an enzyme from catalyzing its reaction. The concentration necessary to inhibit effectively (its potency), and its ability to not bind to other molecules (specificity) are how the quality of new inhibitors are judged. A new inhibitor with a high specificity and potency ensures a drug will have few side effects and low toxicity.

Inhibitor Types

Inhibitors can then be categorized into two categories: reversible or irreversible. Reversible inhibitors are those whose chemical modifications can be undone. Unsurprisingly, irreversible inhibitors covalently modify an enzyme, thus making permanent changes.

Reversible Inhibitors

When reversible inhibitors attach to enzymes, they do not undergo chemical reactions and can thus be effectively removed via dilution or dialysis. To classify reversible inhibitors, scientists look at the effects of varying their concentration.

Types of RI:

Competitive Inhibition: Enzyme’s target substrate and inhibitor compete for the active site.

Uncompetitive Inhibition: The inhibitor is only activated once the substrate binds to the enzyme.

Non-Competitive Inhibition: when the inhibitor merely slows the activity of the enzyme but does not restrict the substrate-enzyme complex formation.

Mixed Inhibition: the inhibitor and substrate can bind to the enzyme at the same time, resulting in a slowing of activity with a reduction in affinity.

Irreversible Inhibitors

Irreversible inhibition occurs when an enzyme is covalently modified. This occurs when a functional group, usually containing nitrogen mustards, aldehydes, haloalkanes, alkenes, Michael acceptors, phenyl sulfonates, or fluorophosphonates bind with the amino acid side chains present on enzymes to form covalent adducts. Such chemical reactions do not denature proteins, but rather alter their specific enzyme’s active site.