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Gene Silencing Kits
DharmaFECT 4 Transfection Reagent
RNAi Type
miRNA, siRNA
miRNA, siRNA
Targets
miRNA, siRNA
miRNA, siRNA
Organism
Animals
Animals
Scientific Score
9.74
Brand
Dharmacon
Sizes
5 (200 - 20000 µl)
Available From
1 Vendor
Price Range
$ 99.00 - $ 2,238.00
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Gene Silencing Kits
Lullaby Stem siRNA Transfection Reagent
RNAi Type
miRNA, siRNA
miRNA, siRNA
Targets
mRNA
mRNA
Organism
Human
Human
Scientific Score
8.29
Brand
OZ Biosciences
Sizes
2 (500 - 1000 µl)
Available From
2 Vendors
Price Range
$ 178.00 - $ 340.59
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Gene Silencing Kits
Accell siRNA Delivery Media
RNAi Type
siRNA
siRNA
Targets
mRNA
mRNA
Organism
Animals, Human
Animals, Human
Scientific Score
9.14
Brand
Dharmacon
Sizes
2 (100 - 500 ml)
Available From
1 Vendor
Price Range
$ 16.00 - $ 37.00
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Gene Silencing Kits
Transfection Medium, Expression Systems
Brand
Expression Systems
Sizes
2 (20 - 100 ml)
Available From
1 Vendor
Price Range
$ 45.77 - $ 154.50
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Gene Silencing Kits
Transfection Selection Kit #4
RNAi Type
/
/
Targets
/
/
Organism
/
/
Scientific Score
4.79
Brand
OZ Biosciences
Sizes
1 (1 Kit)
Available From
1 Vendor
Price
$ 334.75
Catalog IDs
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Gene Silencing Kits
Transfection Starting Kit #2
RNAi Type
/
/
Targets
/
/
Organism
/
/
Scientific Score
4.27
Brand
OZ Biosciences
Sizes
1 (1 Kit)
Available From
1 Vendor
Price
$ 545.90
Catalog IDs
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Gene Silencing Kits
Transfection Starting Kit #3
RNAi Type
/
/
Targets
/
/
Organism
/
/
Scientific Score
3.68
Brand
OZ Biosciences
Sizes
1 (1 Kit)
Available From
1 Vendor
Price
$ 757.05
Catalog IDs
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Gene Silencing Kits
X-tremeGENE™ siRNA Transfection Reagent
RNAi Type
siRNA
siRNA
Targets
Plasmid DNA, siRNA
Plasmid DNA, siRNA
Organism
Animals
Animals
Scientific Score
8.12
Brand
Roche Life Science
Sizes
2 (1000 - 5000 µl)
Available From
1 Vendor
Price Range
$ 264.00 - $ 1,120.00
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Gene Silencing Kits
SilenceMag siRNA Delivery Reagent
RNAi Type
dsRNA, shRNA, siRNA
dsRNA, shRNA, siRNA
Targets
mRNA
mRNA
Organism
Animals, Human
Animals, Human
Scientific Score
8.89
Brand
OZ Biosciences
Sizes
5 (1 - 500 Kit)
Available From
2 Vendors
Price Range
$ 119.00 - $ 1,431.70
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Gene Silencing Kits
ON-TARGETplus Non-targeting Pool
RNAi Type
siRNA
siRNA
Targets
mRNA
mRNA
Organism
Animals, Human
Animals, Human
Scientific Score
9.92
Brand
Dharmacon
Sizes
3 (5 - 50 nmol)
Available From
1 Vendor
Price Range
$ 228.00 - $ 911.00
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Gene Silencing Kits
MISSION® siRNA Transfection Reagent
RNAi Type
/
/
Targets
/
/
Organism
Animals, Human
Animals, Human
Scientific Score
6.07
Brand
Sigma-Aldrich
Sizes
2 (100 - 1000 µl)
Available From
2 Vendors
Price Range
$ 57.00 - $ 431.44
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Gene Silencing Kits
N-TER™ Nanoparticle siRNA Transfection System
RNAi Type
siRNA
siRNA
Targets
mRNA
mRNA
Organism
Animals, Fungi, Human, Insects, Plants, Vertebrates, Yeast
Animals, Fungi, Human, Insects, Plants, Vertebrates, Yeast
Scientific Score
7.86
Brand
Sigma-Aldrich
Sizes
3 (120 - 1000 µl)
Available From
2 Vendors
Price Range
$ 82.50 - $ 517.65
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Gene Silencing Functionality

Gene Silencing refers to a series of gene editing techniques that reduces the transcription or translation of a gene. In contrast with genetic mutations, gene silencing selectively targets the gene of interest with various silencing intensities, taking advantage of the native gene regulation.

Recently, gene silencing was recognised to be crucial in the study of autophagy.

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RNA interference (RNAi)

RNA interference (RNAi) is a widely used gene silencing technique for the regulation of gene expression. Compared to classic mutants, gene silencing techniques can be used with an inducible promoter or under a tissue- or stage-specific control. When choosing an RNAi kit, there are a few factors to consider.

Firstly, whether you use a synthesized siRNA or if you'd prefer to clone your own. The former is a faster, high-quality solution, whereas custom made synthetic siRNA is expensive. On the other hand, in vivo creation of siRNA creates an entire collection of siRNA against a target gene, which increases the chances of a successful silencing. While this is a lengthy process, there are kits that can make the process easier.

Secondly, the method of siRNA delivery in the cell. While synthesized siRNAs can be delivered directly with dedicated reagents or physical methods such as magnetic beads, it is also possible to express RNAs that will be processed in the cell to become siRNAs. This approach requires the use of specific vectors, but is advantageous by using selectable markers or time- and cell-type- specific expression.

Use our Gene Silencing Troubleshoot to fix any problems which arise.

Compare Gene Silencing Kits

With our compare function, you can avoid all the time and energy wasted sifting through multiple web pages from different suppliers. At ZAGENO you can clearly see kits side-by-side, with the relevant attributes for each kit neatly in line for easy selection of the best product for you.

Video Credits:

Video: TED-Ed/YouTube