Specifications

Variant Details
Catalog IDSTJ120152-25UGSupplier Catalog IDSTJ120152
Size25 µgPrice $ 607.60
Supplier St John's Laboratory, US Package Content Anti-NMDAR1 C2 antibody (KLH)
General
ClonalityPolyclonalHostRabbit
ReactivityHuman, Mouse, RatApplicationsImmunohistochemistry, Western Blot
ConjugatedConjugatedConjugate TypeKLH (Keyhole Limpet Hemocyanin)
ImmunogenSynthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2 splice variant insert conjugated to KLH.DilutionWB 1:1000; IHC 1:1000-1:2000
FormulationLyophilizedPurification MethodThis antibody was antigen affinity purified from serum.
Gene ID24408[uid]Alternative Names & SynonymsAnti-Glutamate Receptor Ionotropic-Nmda 1 antibody</br>Anti-Glun1 antibody</br>Anti-Glutamate Nmda Receptor Subunit Zeta-1 antibody</br>Anti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibody</br>Anti-Nmd-R1 antibody</br>Anti-Grin1 Nmdar1 antibody
UniProtKBP35439Swiss-ProtP35439 (NMDZ1_RAT)
Molecular Weight120 kDaAdditional InformationThe ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). There are a number of different splice variants of the NR1 subunit (Foldes et al., 1994; Zukin and Bennett, 1995). Differential splicing of three exons in the NR1 subunit generates up to eight NR1 subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2&#8242;). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
FormLyophilizedShipping Temperature4 °C
Storage & HandlingStore at-20°C, and avoid repeated freeze-thaw cycles.

Description

Currently, no description is available.

For research use only.