Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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|Catalog ID||CCL4-100ug||Supplier Catalog ID||CCL4-100ug|
|Size||100 µg||Price||$ 304.20|
|Supplier||ChemoTactics, Inc.||Package Content||CCL4 (MIP-1β) Chemokine, 100 µg|
|Purity||> 97 %||Molecular Weight||7.818 kDa|
|Solubility||Sterile water||Shipping Temperature||20 °C|
|Storage & Handling||-20 °C||Shelf Life||12 months|
For research use only.