Specifications

Variant Details
Catalog IDCCL4-1mgSupplier Catalog IDCCL4-1mg
Size1 mgPrice $ 1,381.25
Supplier ChemoTactics, Inc. Package Content CCL4 (MIP-1β) Chemokine, 1 mg
General
Applicable Processes/ConjugatedUnconjugated
Purity> 97 %Molecular Weight7.818 kDa
SolubilitySterile waterShipping ConditionRoom temperature
Shipping Temperature20 °CStorage & Handling-20 °C
Shelf Life12 monthsResearch Topics/

Description

Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

For research use only.