Specifications

Variant Details
Catalog IDbs-12301R-Cy3-100ULSupplier Catalog IDbs-12301R-Cy3
Size100 µlPrice $ 391.00
Supplier Bioss Inc. Package Content CDX4 Polyclonal Antibody, Cy3 Conjugated, 100ul
General
AntigenCDX4ClonalityPolyclonal
HostRabbitReactivityHuman, Mouse, Rat
ApplicationsImmunofluorescence, ImmunohistochemistryConjugatedConjugated
Conjugate TypeCy (Cyanine)Specific ConjugateCy3
IsotypeIgGImmunogenKLH conjugated synthetic peptide derived from human CDX4
Concentration1µg/µlDilutionIF(IHC-P)(1:50-200)
Purification MethodPurified by Protein A.GeneCDX4
Gene ID1046 (Homo sapiens)Alternative Names & SynonymsCaudal-type homeobox protein 4; CDX4; CDX4_HUMAN; Homeobox protein CDX-4.
Storage & HandlingStore at 4°C for 12 monthsStorage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide

Description

Cdx1, Cdx2 and Cdx4 are members of the caudal-type homeobox family of genes, which are homologs of the Drosophila “caudal†gene required for anterior-posterior regional identity. The proteins encoded by these genes are transcription factors which play an important role in development by regulating the expression of Hox genes. Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. Cdx4 is a major positive regulator of the expression of all Hox family members. Due to its critical role as a regulator, Cdx4 is a direct target of the canonical Wnt pathway. The loss of Cdx4 can result in the development of an expanded hindbrain, while the overexpression of Cdx4 may cause the hindbrain to lose its distinct segmental features and resemble the spinal cord.

For research use only.

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