Specifications

Variant Details
Catalog IDbs-9502R-100ULSupplier Catalog IDbs-9502R-100UL
Size100 µlPrice N/A
Supplier N/A Package Content Factor 11 light chain Antibody, 100ul
General
ClonalityPolyclonalHostRabbit
ReactivityHuman, Mouse, RatApplicationsImmunofluorescence, Immunohistochemistry, Western Blot
ConjugatedUnconjugatedIsotypeIgG
ImmunogenKLH conjugated synthetic peptide derived from human Coagulation factor XIa light chainConcentration1µg/µl
DilutionWB(1:300-1000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)Purification MethodPurified by Protein A.
GeneFactor 11 light chainGene ID2160 (Homo sapiens)
Alternative Names & SynonymsCoagulation factor XI; Coagulation factor XIa light chain; F11; FA11_HUMAN; FXI; MGC141891; Plasma thromboplastin antecedent; PTA; Factor XI.Storage & HandlingStore at -20°C for 12 months
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide

Description

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008].

For research use only.

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