Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.Sample Type:Cell culture supernates, serum, EDTA plasma, and heparin plasma.Sensitivity:The mean MDD was 12.0pg/ml. The Minimum Detectable Dose (MDD) was determined by adding two standard deviations to the MFI of twenty zero standard replicates and calculating the corresponding concentration. Range:~4.96-21pg/mlSpecificity:Recognizes natural and recombinant human gp130. Test Principle:Human gp130 BioAssay™ Kit afford the user the benefit of multianalyte analysis of biomarkers in a complex sample. For each sample type, a single, multipurpose diluent is used to optimize recovery, linearity, and reproducibility. Such a multipurpose diluent may not optimize any single analyte to the same degree that a unique diluent selected for analysis of that analyte can optimize conditions. Therefore, some performance characteristics may be more variable than those for assays designed specifically for single analyte analysis.Kit Components:Microparticle Concentrate, 100X concentrated, 1x0.075mlBiotin-Antibody Concentrate, 100X concentrated, 1x0.075mlStorage and Stability:Store powder at 4°C liquid at -20°C. Store other components at 4°C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
|Catalog ID||145741-1UNIT||Supplier Catalog ID||145741|
|Size||1 Kit||Price||$ 536.00|
|Supplier||United States Biological Inc.||Package Content||Gp130, Human, BioAssay™ MAP Kit (CD130, IL6ST), 1Kit|
|Shipping Temperature||RT||Storage & Handling||-20°C|
For research use only.