Specifications

Variant Details
Catalog IDRC205568L3Supplier Catalog IDRC205568L3
Size10 µgPrice N/A
Supplier N/A Package Content Lenti ORF clone of Human ring finger protein 217 (RNF217) , Myc-DDK-tagged, 10 ug
General
Vector TypepLenti-C-Myc-DDK-P2A-PuroMolecular Weight31.8 kDa
Antibiotic ResistancePuromycinRestriction sites'SgfI-MluI
Protein Accession No.NM_152553Protein symbolRNF217
Tag TypeMyc-tagAlternative Names & SynonymsC6orf172 | dJ84N20.1 | IBRDC1 | OSTL

Description

This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

For research use only.