This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
|Catalog ID||RC205568L3||Supplier Catalog ID||RC205568L3|
|Supplier||N/A||Package Content||Lenti ORF clone of Human ring finger protein 217 (RNF217) , Myc-DDK-tagged, 10 ug|
|Vector Type||pLenti-C-Myc-DDK-P2A-Puro||Molecular Weight||31.8 kDa|
|Antibiotic Resistance||Puromycin||Restriction sites'||SgfI-MluI|
|Protein Accession No.||NM_152553||Protein symbol||RNF217|
|Tag Type||Myc-tag||Alternative Names & Synonyms||C6orf172 | dJ84N20.1 | IBRDC1 | OSTL|
For research use only.