HIP1R (huntingtin interacting protein 1 related) was first cloned based on its sequence similarity with HIP1 (Huntingtin Interacting Protein 1). HIP1 binds to normal huntingtin but this interaction is lost in Huntington’s disease (HD). HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes. HIP1R colocalizes with and binds to actin and this interaction may link the endocytic machinery to the actin cytoskeletal dynamic processes.Applications: Suitable for use in Immunofluorescence, Western Blot. Other applications not tested.Recommended Dilution:Immunofluorescence: 1:50-1:250Western Blot: 1:500-1:2500Optimal dilutions to be determined by the researcher.Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
|Catalog ID||301674-100UL||Supplier Catalog ID||301674|
|Size||100 µl||Price||$ 599.00|
|Supplier||United States Biological Inc.||Package Content||Rabbit Anti-human Huntingtin-Interacting Protein 1-Related polyclonal antibody SKU:301674, 100 µl|
|Reactivity||Human||Cross Reactivity||Human, Rat|
|Applications||Immunofluorescence, Western Blot||Conjugated||Unconjugated|
|Isotype||IgG||Immunogen||aa sequence of human HIP1R at C-terminal.|
|Specificity||Recognizes human HIP1R.||Dilution||Immunofluorescence: 1:50-1:250Western Blot: 1:500-1:2500Optimal dilutions to be determined by the researcher.|
|Gene||Huntingtin-Interacting Protein 1-Related||UniProtKB||O75146|
|Form||Lyophilized||Shipping Temperature||Blue Ice|
|Storage & Handling||-20°C||Purity||Ascites|
For research use only.