Specifications

Variant Details
Catalog ID220356-5UGSupplier Catalog ID220356
Size5 µgPrice $ 526.00
Supplier United States Biological Inc. Package Content TrkB, Active, Recombinant, Human (Neurotrophic Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, Tropomyosin-related Kinase B) , 5ug
General
SourceRecombinant, Baculovirus (Sf9 insect cells)Additional InformationSupplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Shipping TemperatureBlue IceStorage & Handling-20°C

Description

TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.Source:Recombinant protein corresponding to human TrkB, expressed in Baculovirus (Sf9 insect cells). Molecular Weight: ~67kDSpecific Activity:~74nmol/min/mg as per activity assay protocolStorage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

For research use only.