Specifications

Variant Details
Catalog ID220407-10UGSupplier Catalog ID220407-10ug
Size10 µgPrice $ 462.00
Supplier United States Biological Inc. Package Content UPK3A, Recombinant, Human (Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A), 10ug
General
SourceRecombinant, E. coliPurity~90% (SDS-PAGE)
Additional InformationSupplied as a liquid in 20mM Tris-HCl, pH 8.0, 150mM NaCl, 2mM DTT, 20% glycerol.Shipping TemperatureRT
Storage & Handling-20°C

Description

UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.Source:Recombinant protein corresponding to human UPK3A, expressed in E. coli. Molecular Weight: ~23.1kDAA Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGGStorage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

For research use only.