Specifications

Variant Details
Catalog IDbs-12271R-Cy7-100ULSupplier Catalog IDbs-12271R-Cy7-100UL
Size100 µlPrice N/A
Supplier N/A Package Content YBOX2 Polyclonal Antibody, Cy7 Conjugated, 100ul
General
AntigenYBX2ClonalityPolyclonal
HostRabbitReactivityHuman, Mouse, Rat
ApplicationsImmunofluorescence, ImmunohistochemistryConjugatedConjugated
Conjugate TypeCy (Cyanine)Specific ConjugateCy7
IsotypeIgGImmunogenKLH conjugated synthetic peptide derived from human YBOX2
Concentration1µg/µlDilutionIF(IHC-P)(1:50-200)
Purification MethodPurified by Protein A.GeneMSY2/YBOX2/DBPC
Gene ID51087 (Homo sapiens)Storage & HandlingStore at 4°C for 12 months
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide

Description

MSY2 and YB-2 (MSY3,4) belong to the Y-box family of multifunctional proteins that regulate both transcription and translation. Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins (1). The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing arginine clusters and aromatic residues (4). MSY2 is expressed in testis and ovary where it may repress translation of parental mRNA (5,6). The gene encoding human MSY2 maps to chromosome 17p11.2-13.1 (5). YB-2 (MSY3,4 in mouse) is also known as DNA binding protein A and is highly expressed in the testis, heart and muscle (7,8). MSY2 and YB-2 bind to the consensus sequence 5'-UCCAUCA-3' contained in the Y-box element (9).

For research use only.

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